Purpose

Because of the increase in globalization, clinicians all over the world are confronted the questions about safety of Ramadan fasting. However, there is no clear information about whether there is an obstacle for fasting patients with chronic disease. Hence, in the present study, we aimed to investigate the effects of Ramadan fasting on kidney and the factors affecting this relationship in patients with chronic kidney disease.

Methods

This study involving 117 patients [36 females, 81 males; mean age, 60 (46.0–70.0) years] with stage 2–3 chronic kidney and fasting. Patients were evaluated every 10 days for acute kidney injury (AKI) in Ramadan month. And, patients with acute kidney injury and patients without AKI were grouped.

Results

When the patients were evaluated for AKI, we observed that in 27 patients had acute kidney injury. While patients without AKI fasted for more days (p < 0.001), urea levels and frequency of hypertension were higher in the group with AKI (p = 0.019; p = 0.025 respectively). We also performed univariate and multiple binary logistic regression analysis to identify the risk factors of AKI. Hypertension and number of fasting day were found to be predictive of AKI (p = 0.02; p < 0.001 respectively).

Conclusions

We found a significant relationship between hypertension, the number of fasting days and acute kidney injury. Patients with chronic kidney damage and hypertension should be evaluated more carefully, informed about the importance of hydration after fasting and should be followed frequently for AKI.

中文翻译：

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斋月禁食对慢性肾脏病患者肾脏功能的影响。

目的

由于全球化的加剧，全世界的临床医生都面临着斋月斋戒安全的问题。但是，对于禁食慢性病患者是否存在障碍，尚无明确信息。因此，在本研究中，我们旨在研究斋月禁食对肾脏的影响以及影响慢性肾脏病患者这种关系的因素。

方法

该研究涉及117名患者[36名女性，81名男性；平均年龄为60（46.0-70.0）岁，患有2–3期慢性肾脏和禁食。在斋月期间，每10天评估一次患者的急性肾损伤（AKI）。并且，将具有急性肾损伤的患者和没有AKI的患者分组。

结果

当评估患者的AKI时，我们观察到27例急性肾损伤。没有AKI的患者禁食更多天（p  <0.001），而AKI组的尿素水平和高血压发生率更高（ 分别为p  = 0.019; p = 0.025）。我们还进行了单变量和多元二元logistic回归分析，以确定AKI的危险因素。发现高血压和禁食天数可预测AKI（p  = 0.02；p  <0.001）。

结论

我们发现高血压，禁食天数和急性肾损伤之间存在显着关系。慢性肾脏损伤和高血压患者应进行更仔细的评估，了解禁食后水化的重要性，并应经常进行AKI随访。