Purpose

Polycystic ovarian syndrome (PCOS) is a common disorder characterized by clinical or biochemical hyperandrogenism and ovulary dysfunction. Female sexual dysfunction (FSD) adversely affects quality of life and interpersonal relationships. We aimed to compare the prevalence of FSD in women with and without PCOS.

Methods

We pooled data from 28 observational studies involving 6256 women. Apart from the total prevalence of FSD, subgroup analyses based on different PCOS diagnostic criteria and obesity status (body mass index [BMI] ≥ 25 kg/m²) were performed. The differences in total and subscale scores of the Female Sexual Function Index (FSFI) among women with and without PCOS were also compared.

Results

Women with PCOS were younger (mean ± SD 28.56 ± 3.0 vs 31.5 ± 3.2 years, p < 0.001) with higher BMI (28.5 ± 4.2 vs 27.0 ± 6.1 kg/m², p < 0.001), Ferriman-Gallwey score (10.0 ± 3.2 vs 4.0 ± 2.1, p < 0.001), and serum total testosterone level (2.34 ± 0.58 nmol/L vs 1.57 ± 0.60 nmol/L, p < 0.001) compared with women without PCOS. The prevalence of FSD among women with and without PCOS was 35% and 29.6%, respectively. There was no significant difference in total FSFI score (24.59 ± 3.97 vs 26.04 ± 3.05, p = 0.237) between the two groups. Women with PCOS, however, had significantly lower scores in the pain (p < 0.001) and satisfaction subscales (p = 0.010) compared with women without PCOS. Women with PCOS had 1.32 higher odds (95% CI 1.07, 1.61) of having FSD than women without PCOS.

Conclusion

Women with PCOS have a higher risk of FSD than those without PCOS. Although total FSFI scores were not significantly different, women with PCOS tended to report dyspareunia and lack of sexual satisfaction.

中文翻译：

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多囊卵巢综合征的性功能障碍：系统评价和荟萃分析。

目的

多囊卵巢综合征（PCOS）是一种常见疾病，其特征是临床或生化高雄激素血症和卵泡功能障碍。女性性功能障碍（FSD）对生活质量和人际关系产生不利影响。我们旨在比较有无PCOS的女性中FSD的患病率。

方法

我们汇总了28项涉及6256名妇女的观察性研究的数据。除了FSD的总患病率外，还根据不同的PCOS诊断标准和肥胖状况（体重指数[BMI]≥25 kg / m ²）进行了亚组分析。还比较了有和没有PCOS的女性中女性性功能指数（FSFI）的总分和分量表得分的差异。

结果

患有PCOS的女性更年轻（平均±SD 28.56±3.0 vs 31.5±3.2岁，p  <0.001），BMI较高（28.5±4.2 vs 27.0±6.1 kg / m ²，p  <0.001），Ferriman-Gallwey评分（10.0± 与没有PCOS的女性相比，分别为3.2 vs 4.0±2.1，p  <0.001）和血清总睾丸激素水平（2.34±0.58 nmol / L与1.57±0.60 nmol / L，p <0.001）。有和没有PCOS的女性中FSD的患病率分别为35％和29.6％。两组之间的FSFI总评分无显着差异（24.59±3.97 vs 26.04±3.05，p  = 0.237）。然而，患有PCOS的女性在疼痛（p  <0.001）和满意度量表（p = 0.010），而没有PCOS的女性则比较。与没有PCOS的女性相比，患有PCOS的女性患FSD的几率高1.32（95％CI 1.07，1.61）。

结论

与没有PCOS的女性相比，患有PCOS的女性患FSD的风险更高。尽管FSFI总分没有显着差异，但患有PCOS的女性倾向于报告性交困难和缺乏性满足感。