Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the DYRK class II members, DYRK2 is considered a unique protein due to its role in disease. According to the post-transcriptional and post-translational modifications, DYRK2 expression greatly differs among human tissues. Regarding its mechanism of action, this kinase performs direct phosphorylation on its substrates or acts as a priming kinase, enabling subsequent substrate phosphorylation by GSK3β. Moreover, DYRK2 acts as a scaffold for the EDVP E3 ligase complex during the G2/M phase of cell cycle. DYRK2 functions such as cell survival, cell development, cell differentiation, proteasome regulation, and microtubules were studied in complete detail in this review. We have also gathered available information from different bioinformatic resources to show DYRK2 interactome, normal and tumoral tissue expression, and recurrent cancer mutations. Then, here we present an innovative approach to clarify DYRK2 functionality and importance. DYRK2 roles in diseases have been studied in detail, highlighting this kinase as a key protein in cancer development. First, DYRK2 regulation of c-Jun, c-Myc, Rpt3, TERT, and katanin p60 reveals the implication of this kinase in cell-cycle-mediated cancer development. Additionally, depletion of this kinase correlated with reduced apoptosis, with consequences on cancer patient response to chemotherapy. Other functions like cancer stem cell formation and epithelial–mesenchymal transition regulation are also controlled by DYRK2. Furthermore, the pharmacological modulation of this protein by different inhibitors (harmine, curcumine, LDN192960, and ID-8) has enabled to clarify DYRK2 functionality.

双特异性酪氨酸调节激酶​​ (DYRK) 亚家族的成员具有独特的磷酸化酪氨酸、丝氨酸和苏氨酸残基的能力。在 DYRK II 类成员中，DYRK2 由于其在疾病中的作用而被认为是一种独特的蛋白质。根据转录后和翻译后修饰，DYRK2 的表达在人体组织中存在很大差异。关于其作用机制，该激酶对其底物进行直接磷酸化或充当引发激酶，从而使 GSK3β 能够随后进行底物磷酸化。此外，DYRK2 在细胞周期的 G2/M 期充当 EDVP E3 连接酶复合物的支架。本综述对 DYRK2 功能（例如细胞存活、细胞发育、细胞分化、蛋白酶体调节和微管）进行了完整详细的研究。我们还从不同的生物信息资源收集了可用信息，以显示 DYRK2 相互作用组、正常和肿瘤组织表达以及复发性癌症突变。然后，我们在这里提出一种创新方法来阐明 DYRK2 的功能和重要性。 DYRK2 在疾病中的作用已得到详细研究，强调该激酶是癌症发展中的关键蛋白。首先，DYRK2 对 c-Jun、c-Myc、Rpt3、TERT 和 katanin p60 的调节揭示了该激酶在细胞周期介导的癌症发展中的含义。此外，这种激酶的消耗与细胞凋亡减少相关，从而影响癌症患者对化疗的反应。其他功能如癌症干细胞形成和上皮-间质转化调节也由 DYRK2 控制。 此外，不同抑制剂（去氢骆驼蓬碱、姜黄素、LDN192960 和 ID-8）对该蛋白的药理学调节使得能够阐明 DYRK2 的功能。