Molecular and nanoengineering approaches towards activatable cancer immunotherapy.,Chemical Society Reviews

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Molecular and nanoengineering approaches towards activatable cancer immunotherapy.
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-05-26 , DOI: 10.1039/c9cs00773c
Chi Zhang ₁ , Kanyi Pu ₁

Affiliation

Cancer immunotherapy is an emerging treatment strategy that modulates the immune system to fight against cancer. Although several immunotherapeutic agents have been utilized in the clinic for cancer treatment, low patient response rates and potential immune-related adverse events remain two major challenges. With the merits of delivery controllability and modular flexibility, nanomedicines provide opportunities to facilitate immunotherapies for clinical translation in a safe and effective manner. In this review, we discuss the convergence of nanomedicine with immunotherapy with a focus on molecular and nanoengineering approaches towards activatable cancer immunotherapy. These activatable nanoagents exert immunotherapeutic action only in response to internal or external stimuli. This allows them to locally reprogram the tumor microenvironment and activate antitumor immunity while reducing the incidence of immune-related adverse events. The category of activatable immunotherapeutic nanoagents are discussed along with an overview of their clinical translation prospects and challenges.

中文翻译：

分子和纳米工程方法可激活的癌症免疫疗法。

癌症免疫疗法是一种新兴的治疗策略，可调节免疫系统抵抗癌症。尽管临床上已经将几种免疫治疗剂用于癌症治疗，但是低的患者反应率和潜在的免疫相关不良事件仍然是两个主要挑战。凭借递送可控性和模块化灵活性的优点，纳米药物提供了以安全有效的方式促进用于临床翻译的免疫疗法的机会。在这篇综述中，我们讨论了纳米医学与免疫疗法的融合，重点是针对可激活的癌症免疫疗法的分子和纳米工程方法。这些可激活的纳米剂仅对内部或外部刺激产生免疫治疗作用。这使他们能够局部重编程肿瘤微环境并激活抗肿瘤免疫力，同时减少免疫相关不良事件的发生率。讨论了可活化免疫治疗纳米剂的类别，并概述了其临床翻译前景和挑战。

更新日期：2020-07-06

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