Sex-Specific Metabolic Changes in Peripheral Organs of Diabetic Mice.,Journal of Proteome Research

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Sex-Specific Metabolic Changes in Peripheral Organs of Diabetic Mice.
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2020-05-25 , DOI: 10.1021/acs.jproteome.0c00049
Xi Zhang ₁ , Hangying Xu ₁ , Jie Ning ₁ , Hui Ji ₁ , Junjie Yan ₁ , Yafei Zheng ₁ , Qingqing Xu ₁ , Chen Li ₁ , Liangcai Zhao ₁ , Hong Zheng ₁ , Hongchang Gao ₁

Affiliation

Diabetes mellitus (DM) can cause systemic metabolic disorders, but the impact of gender on DM-related metabolic changes is rarely reported. Herein, we analyzed metabolic alterations in the heart, liver, and kidney of male and female mice from normal to diabetes via a ¹H NMR-based metabolomics method and aimed to investigate sex-specific metabolic mechanisms underlying the onset and development of diabetes and its complications. Our results demonstrate that male mice had more significant metabolic disorders from normal to diabetes than female mice. Moreover, the kidney was found as the major organ of metabolic disorders during the development of diabetes, followed by the liver and heart. These altered metabolites were mainly implicated in energy metabolism as well as amino acid, choline, and nucleotide metabolism. Therefore, this study suggests that the kidney is the primary organ affected by diabetes in a sex-specific manner, which provides a metabolic view on the pathogenesis of diabetic kidney diseases between genders.

中文翻译：

糖尿病小鼠外周器官的特定性别代谢变化。

糖尿病（DM）可以引起全身性代谢紊乱，但很少有人报道性别对与DM相关的代谢变化的影响。在这里，我们分析了从正常到糖尿病的雄性和雌性小鼠的心脏，肝脏和肾脏的代谢变化，其变化通过¹基于1 H NMR的代谢组学方法，旨在研究构成糖尿病及其并发症的潜在性别特异性代谢机制。我们的研究结果表明，从正常到糖尿病，雄性小鼠比雌性小鼠具有更大的代谢异常。此外，发现肾脏是糖尿病发展过程中代谢紊乱的主要器官，其次是肝脏和心脏。这些改变的代谢物主要与能量代谢以及氨基酸，胆碱和核苷酸代谢有关。因此，这项研究表明，肾脏是按性别区分的受糖尿病影响的主要器官，这为男女之间糖尿病性肾脏疾病的发病机理提供了新的观点。

更新日期：2020-05-25

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