Knee osteoarthritis (OA) is the most common form of OA which affects knee joints and there is currently no disease-modifying treatment available for OA. Therefore, an ideal strategy to prevent the development of OA is to identify and intervene at the modifiable risk factors for the development and progression of OA. Early-life factors such as obesity and malalignment may affect the mechanical aspect of the knee (i.e. alterations in normal knee kinematics) and could be the risk factor for the development of knee OA in later life. Identifying early-life (gestational factors, congenital defects, childhood, adolescence, early adulthood) factors which affect the development of knee OA in later stages of the life may help to develop targeted prevention programs in early-life itself to prevent the development of knee OA. Hence, this systematic review protocol provides the method to be used to comprehensively summarise the existing evidence on early life modifiable risk factors associated with the development and progression of knee OA.

中文翻译：

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膝关节骨关节炎发展的早期生活可修改危险因素：系统评价方案

膝骨关节炎（OA）是影响膝关节的最常见形式的OA，目前尚无可用于OA的疾病缓解疗法。因此，防止OA发生的理想策略是识别和干预OA发生和发展的可改变风险因素。肥胖和畸形等早期生命因素可能会影响膝盖的机械方面（即正常的膝关节运动学改变），并且可能是以后生活中膝骨关节炎发展的危险因素。识别会影响膝盖OA发展的早期生命（妊娠因素，先天性缺陷，童年，青春期，成年早期）因素可能有助于在生命早期制定针对性的预防计划，以预防膝盖的发育OA。因此，