Non-alcoholic fatty liver disease (NAFLD) includes a range of disorders from simple steatosis to non-alcoholic steatohepatitis. There is no proven drug treatment for NAFLD, and diet modification is considered part of the main line of treatment for this disease. The aim of this study was to investigate the efficacy of garlic supplementation in NAFLD patients. The effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile was investigated in NAFLD patients. Ninety NAFLD patients were randomly assigned to take either a garlic powder supplement or a placebo for 12 weeks. The treatment group received four tablets of garlic daily (each tablet contained 400 mg garlic powder). The control group received four tablets of placebo (each placebo contained 400 mg starch). At the end of the study, hepatic steatosis was significantly reduced in the treatment group compared with the control group (P = 0·001). In addition, a significant decrease was seen in the serum concentration of alanine transaminase (P < 0·001), aspartate transaminase (P = 0·002), γ-glutamyltransferase (P = 0·003) as well as total cholesterol (P = 0·009), TAG (P < 0·001), HDL-cholesterol (P < 0·001) and LDL-cholesterol (P = 0·01) in the treatment group compared with the control group. No significant difference was seen between the two groups in serum concentration of alkaline phosphatase. Overall, garlic powder supplementation improved hepatic features and lipid profile among NAFLD patients.

中文翻译：

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大蒜粉补充剂对非酒精性脂肪肝患者肝脂肪变性、肝酶和血脂的影响：一项双盲随机对照临床试验

非酒精性脂肪性肝病 (NAFLD) 包括从单纯性脂肪变性到非酒精性脂肪性肝炎的一系列疾病。没有经过验证的 NAFLD 药物治疗，饮食调整被认为是治疗这种疾病的主线的一部分。本研究的目的是调查大蒜补充剂对 NAFLD 患者的疗效。研究了在 NAFLD 患者中补充大蒜粉对肝脏脂肪变性、肝酶和脂质谱的影响。90 名 NAFLD 患者被随机分配服用大蒜粉补充剂或安慰剂，为期 12 周。治疗组每天服用4片大蒜（每片含400毫克大蒜粉）。对照组接受四片安慰剂（每片安慰剂含有 400 毫克淀粉）。在研究结束时，磷= 0·001)。此外，血清丙氨酸转氨酶浓度显着降低（磷< 0·001), 天冬氨酸转氨酶 (磷= 0·002), γ-谷氨酰转移酶 (磷= 0·003) 以及总胆固醇 (磷= 0·009), 标记 (磷< 0·001), HDL-胆固醇 (磷< 0·001) 和 LDL-胆固醇 (磷= 0·01) 治疗组与对照组比较。两组血清碱性磷酸酶浓度无显着差异。总体而言，大蒜粉补充剂改善了 NAFLD 患者的肝脏功能和血脂状况。