Symptoms of Staphylococcus lugdunensis infection are often similar to those of Staphylococcus aureus infection, including skin and soft-tissue lesions, bacteremia and infective endocarditis. Despite the severity of these infections, S. lugdunensis is regarded as a less important pathogen than drug-resistant S. aureus. To investigate its ability to cause infectious diseases, a methicillin-resistant S. lugdunensis (MRSL) strain JICS135 was isolated from a patient with bacteremia and subjected to whole genome sequencing. Similar to most strains of methicillin-resistant S. aureus (MRSA), this MRSL strain possessed the staphylococcal cassette chromosome mec (SCCmec) located close to the origin of replication. However, the SCCmec in this MRSL strain, with three ccr complexes, was structurally unique and currently untypable. Moreover, the SCCmec of this MRSL strain was found to carry two genes encoding microbial surface components recognizing adhesive matrix molecules (MSCRAMM)-like proteins accompanied by glycosyl transferases, one of which may have been derived from S. aureus and the other from S. epidermidis, indicating that this MRSL evolved to carry virulence factors from other staphylococci. The emergence of this strain, the first MRSL strain whose genome has been sequenced completely, may be of public concern.

Lugdunensis葡萄球菌感染的症状通常与金黄色葡萄球菌感染的症状相似，包括皮肤和软组织损伤，菌血症和感染性心内膜炎。尽管这些感染的严重性，但与耐药的金黄色葡萄球菌相比，卢格敦链球菌被认为是次重要的病原体。探讨其引起传染病的能力，耐甲氧西林S.路邓（MRSL）株JICS135从用菌血症患者分离并进行全基因组测序。与大多数耐甲氧西林金黄色葡萄球菌（MRSA）菌株相似，此MRSL菌株具有葡萄球菌盒式染色体mec（SCC）mec）位于复制起点附近。然而，SCC MEC在这个MRSL应变，有三个CCR复合物，是结构独特，目前untypable。此外，SCC MEC此MRSL菌株被发现携带编码微生物表面组分识别伴随着糖基转移酶，粘附基质分子（MSCRAMM）样蛋白两个基因其中之一可以被衍生自金黄色葡萄球菌和其他从小号表皮霉菌，表明该MRSL进化为携带其他葡萄球菌的致病因子。该菌株是其基因组已完全测序的第一个MRSL菌株，可能引起公众关注。