Introduction

Dengue infection is the most important mosquito-borne viral disease in the world. Most mosquito control methods currently available for public health use are not very efficacious. Dengue vaccine is required to control dengue diseases in the future through the use of a safe and effective vaccine.

Areas covered

This review covered dengue vaccine development and candidate dengue vaccines in the clinical trial pipeline including licensed dengue vaccine.

Expert opinion

Dengue has become an intractable global health problem. Vector control has achieved only limited success in reducing the transmission of dengue. A dengue vaccine is needed as part of an integrated approach to dengue prevention and control since dengue poses a heavy economic cost to the health system and society. Because dengue is a unique and complex disease developing a dengue vaccine has proven equally complex. However, there is an advanced pipeline of vaccine research currently in clinical and preclinical studies including live-attenuated vaccine candidates as well as virus-vectored and virus-like particle-based vaccines.

中文翻译：

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登革热疫苗：预防的关键。

介绍

登革热感染是世界上最重要的蚊媒病毒性疾病。当前可用于公共卫生的大多数蚊子控制方法不是很有效。未来需要通过使用安全有效的疫苗来控制登革热疾病。

覆盖区域

这篇综述涵盖了登革热疫苗的开发以及临床试验中包括授权登革热疫苗在内的候选登革热疫苗。

专家意见

登革热已成为棘手的全球性健康问题。矢量控制在减少登革热传播方面仅取得了有限的成功。登革热疫苗是预防和控制登革热的综合方法的一部分，因为登革热给卫生系统和社会造成了沉重的经济损失，因此需要。由于登革热是一种独特而复杂的疾病，因此开发登革热疫苗已被证明同样复杂。但是，目前在临床和临床前研究中，有一条先进的疫苗研究渠道，包括减毒活疫苗以及基于病毒载体和类病毒颗粒的疫苗。