Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in upper airway, lower airway and lung tissue samples using 16S rDNA analysis. Bacterial density decreased stepwise from upper to lower airways and tissue. On a taxonomic level upper and lower airway microbiota were similar whereas lung tissue showed marked dissimilarities compared to lower airways that may reflect different environmental conditions shaping local microbiota and host immunity.

中文翻译：

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接受肺癌手术的吸烟者的气道和肺组织微生物群的差异。

人的气道被微生物群的微量抽吸连续地定殖。对于肺实质中微生物群的存在，起源和组成知之甚少。在一项针对13位接受手术治疗的周围型肺癌患者的研究中，使用16S rDNA分析比较了上呼吸道，下呼吸道和肺组织样本中的微生物群组成。细菌密度从上呼吸道和下呼吸道和组织逐渐降低。在分类学上，上呼吸道和下呼吸道菌群相似，而与下呼吸道相比，肺组织显示出明显的差异，这可能反映了塑造局部微生物群和宿主免疫力的不同环境条件。