Anthocyanins are water-soluble plant pigments, and based on their chemical structure (nature, position, and the number of sugar moieties attached; the number of hydroxyl groups; acylation of sugars with acids) about 635 different anthocyanins have been identified and reported from plants. Cyanidin, peonidin, pelargonidin, petunidin, and malvidin are the commonly found anthocyanidins (aglycon forms of anthocyanins) in edible plants out of almost 25 anthocyanidins that are identified (based on the position of methoxyl and hydroxyl groups in the rings) in nature. Anthocyanins are known for numerous health benefits including anti-diabetes, anti-obesity, anti-inflammatory bowel disease, anti-cancer, etc. Obesity can be defined as excessive or abnormal adipose tissue and body mass, which increases the risk of developing chronic diseases such as diabetes, cardiovascular diseases, cancers, etc. The manuscript summarizes the recent updates in the effects of anthocyanins supplementation on the health status of obese subjects, and briefly the results of in vitro and in vivo studies. Several studies confirmed that the consumption of anthocyanins-rich food improved obesity-associated dysbiosis in gut microbiota and inflammation in adipose tissue. Anthocyanin consumption prevents obesity in healthy subjects, and aids in maintaining or reducing the body weight of obese subjects, also improving the metabolism and energy balance. Though preclinical studies proved the beneficial effects of anthocyanins such as the fact that daily intake of anthocyanin rich fruits and vegetables might aid weight maintenance in every healthy individual, Juҫara pulp might control the inflammatory status of obesity, Queen garnet plum juice reduced the blood pressure and risk factors associated with metabolic disorders, and highbush organic blueberries improved the metabolism of obese individuals, we don’t have an established treatment procedure to prevent or manage the over-weight condition and its comorbidities. Thus, further studies on the optimum dose, duration, and mode of supplementation of anthocyanins are required to develop an anthocyanins-based clinical procedure.

中文翻译：

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补充花色苷对肥胖相关合并症的影响：简明综述。

花青素是水溶性的植物色素，根据它们的化学结构（性质，位置和附着的糖部分的数量；羟基的数量；糖与酸的酰化作用），已经从植物中鉴定出并报告了约635种花色苷。 。氰胺，peonidin，pelargonidin，petunidin和malvidin是可食用植物中通常发现的自然界中将近25种花青素（基于环中甲氧基和羟基的位置）中的花青素（花青素的苷元形式）。花青素因具有许多健康益处而广为人知，包括抗糖尿病，抗肥胖，抗炎肠病，抗癌等。肥胖可定义为过多或异常的脂肪组织和体重，从而增加了患上慢性病的风险例如糖尿病 该手稿总结了花青素补充剂对肥胖受试者健康状况的影响的最新进展，并简要介绍了体内和体外研究的结果。数项研究证实，食用富含花青素的食物可改善肠道微生物群中与肥胖相关的营养不良和脂肪组织的炎症。食用花青素可预防健康受试者的肥胖，并有助于维持或减轻肥胖受试者的体重，还改善了新陈代谢和能量平衡。尽管临床前研究证明了花青素的有益效果，例如每天摄入富含花青素的水果和蔬菜可以帮助维持每个健康个体的体重，但Juҫara浆可以控制肥胖症的炎症状态，石榴石皇后李子汁可降低血压和与代谢异常相关的危险因素，而高丛有机蓝莓可改善肥胖者的新陈代谢，我们尚无既定的治疗程序来预防或控制超重情况及其合并症。因此，需要进一步研究花青素的最佳剂量，持续时间和补充方式，以开发基于花青素的临床程序。