Synthesis of Bulky 1,1‐Diarylalkanes by Copper‐Catalyzed 1,2‐Alkylarylation of Styrenes with α‐Carbonyl Alkyl Bromides and Arenes involving C−H Functionalization,Advanced Synthesis & Catalysis

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Synthesis of Bulky 1,1‐Diarylalkanes by Copper‐Catalyzed 1,2‐Alkylarylation of Styrenes with α‐Carbonyl Alkyl Bromides and Arenes involving C−H Functionalization
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-05-25 , DOI: 10.1002/adsc.202000363
Shu‐Zheng Luo ₁ , Man‐Yi Min ₁ , Yan‐Chen Wu ₁ , Shuai‐Shuai Jiang ₁ , Yu‐Ting Xiao ₁ , Ren‐Jie Song ₁ , Jin‐Heng Li _{1,

2}

Affiliation

A copper and silver‐promoted intermolecular 1,2‐alkylarylation of styrenes with α‐carbonyl alkyl bromides and arenes for producing highly bulky 1,1‐diarylalkane derivatives has been developed. In this transformations, two new C−C bonds were formed in a single reaction step through C−Br bond cleavage and C(sp ²)−H functionalization. This protocol tolerates a variety of α‐carbonyl alkyl bromides, including primary, secondary and tertiary α‐bromoalkyl ketone esters.

中文翻译：

铜催化苯乙烯与1,2-羰基烷基溴化物和芳烃的苯乙烯催化1,2-烷基芳基化反应，合成大体积的1,1-二芳基烷烃

已开发出铜和银促进的苯乙烯与α-羰基烷基溴化物和芳烃的分子间1,2-烷基芳基化反应，以生产大体积的1,1-二芳基烷烃衍生物。在这种转变中，通过C-Br键断裂和C（sp ²）-H功能化，在一个反应步骤中形成了两个新的C-C键。该方案可耐受多种α-羰基烷基溴化物，包括伯，仲和叔α-溴烷基酮酯。

更新日期：2020-07-29

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