Germline variations in the BRCA‐1 and BRCA‐2 genes are associated with an increased risk of breast cancer. These variants are found in 5% of all breast cancer cases. Prophylactic mastectomy is the most effective risk‐reducing method and shows high rates of patient satisfaction and acceptance. We established a registry of Austrian BRCA‐1 and BRCA‐2 mutation carriers who had undergone mastectomy for oncologic or prophylactic reasons. Data were collected on the type of operation, complications, and type of reconstructive surgery for patients between 2014 and 2017. The complication rate in patients with nipple‐sparing mastectomy was significantly lower (23.1%) than in those with other types of mastectomies (60.7%; P = .005). In patients with implant‐based breast reconstruction, subpectoral placement was associated with a significantly higher rate of complications than prepectoral placement (P = .025). Median implant volume was 350 cc (range: 155‐650 cc), and a 100‐cc increase was associated with doubling of the odds of a complication (regression coefficient = 0.007); based on this finding, some surgeons may decide on using smaller implants. In summary, we identified significant associations between the risk of complications and surgical characteristics, and found host factors like diabetes, BMI, and smoking among Austrian patients with BRCA‐1 and BRCA‐2 variants.

中文翻译：

---

接受预防性乳房切除术的妇女的并发症发生率：奥地利注册机构。

BRCA-1和BRCA-2基因的种系变异与罹患乳腺癌的风险增加相关。在所有乳腺癌病例中有5％发现了这些变异。预防性乳房切除术是最有效的降低风险的方法，显示出较高的患者满意度和接受率。我们建立了奥地利BRCA-1和BRCA-2突变携带者的注册表，这些携带者由于肿瘤或预防原因而接受了乳房切除术。收集了2014年至2017年间患者的手术类型，并发症和重建手术类型的数据。保留乳头的乳房切除术的并发症发生率（23.1％）显着低于其他类型的乳房切除术（60.7） ％; P = .005）。在以植入物为基础的乳房再造患者中，与前胸放置相比，胸下放置的并发症发生率显着更高（P  = .025）。植入物的中位数为350 cc（范围：155-650 cc），并且增加100-cc与并发症几率加倍相关（回归系数= 0.007）；基于此发现，一些外科医生可能会决定使用较小的植入物。总之，我们确定了并发症风险与手术特征之间的显着关联，并发现了患有BRCA-1和BRCA-2变异的奥地利患者中的宿主因素，例如糖尿病，BMI和吸烟。