Clinical studies in radiation therapy with conventional fractionation show a reduction in the tumor control probability (TCP) with an increase in the total and hypoxic tumor volumes. The main objective of this article is to derive an analytical relationship between the TCP and the hypoxic and total tumor volumes. This relationship is applied to clinical data on the TCP reduction with increasing total tumor volume and, also, dose escalation to target tumor hypoxia.

中文翻译：

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TCP在缺氧和氧化性肿瘤中的体积效应。

常规分割放射治疗的临床研究表明，随着总和缺氧肿瘤体积的增加，肿瘤控制概率（TCP）降低。本文的主要目的是得出TCP与缺氧和总肿瘤体积之间的分析关系。这种关系适用于随着总肿瘤体积的增加而TCP减少的临床数据，以及针对目标肿瘤缺氧的剂量递增。