Emerging landscape of circular RNAs as biomarkers and pivotal regulators in osteosarcoma.,Journal of Cellular Physiology

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Emerging landscape of circular RNAs as biomarkers and pivotal regulators in osteosarcoma.
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-05-26 , DOI: 10.1002/jcp.29754
Chao Tu _{1,

2} , Jieyu He ₃ , Lin Qi ₁ , Xiaolei Ren ₁ , Chenghao Zhang ₁ , Zhixi Duan ₁ , Kexin Yang ₄ , Wanchun Wang _{1,

2} , Qiong Lu ₅ , Zhihong Li _{1,

2}

Affiliation

Osteosarcoma represents the most prevailing primary bone tumor and the third most common cancer in children and adolescents worldwide. Among noncoding RNAs, circular RNAs (circRNAs) refer to a unique class in the shape of a covalently closed continuous loop with neither 5′ caps nor 3′‐polyadenylated tails, which are generated through back‐splicing. Recently, with the development of whole‐genome and transcriptome sequencing technologies, a growing number of circRNAs have been found aberrantly expressed in multiple diseases, including osteosarcoma. circRNA are capable of various biological functions including miRNA sponge, mediating alternatives, regulating genes at posttranscriptional levels, and interacting with proteins, indicating a pivotal role of circRNA in cancer initiation, progression, chemoresistance, and immune response. Moreover, circRNAs have been thrust into the spotlight as potential biomarkers and therapeutic targets in osteosarcoma. Herein, we briefly summarize the origin and biogenesis of circRNA with current knowledge of circRNA in tumorigenesis of osteosarcoma, aiming to elucidate the specific role and clinical implication of circRNAs in osteosarcoma.

中文翻译：

环状RNA作为骨肉瘤中生物标志物和关键调节剂的新兴景观。

骨肉瘤是全球儿童和青少年中最普遍的原发性骨肿瘤和第三大最常见的癌症。在非编码RNA中，环状RNA（circRNA）指的是独特的一类，其形式是共价闭合的连续环，既没有5'帽，也没有3'-聚腺苷酸的尾巴，这是通过反向剪接产生的。近年来，随着全基因组和转录组测序技术的发展，发现越来越多的circRNA在多种疾病中异常表达，包括骨肉瘤。circRNA具有多种生物学功能，包括miRNA海绵，介导其他途径，在转录后水平调节基因以及与蛋白质相互作用，这表明circRNA在癌症的发生，发展，化学抗性和免疫应答中起着关键作用。此外，circRNA作为骨肉瘤中潜在的生物标志物和治疗靶点已引起人们的关注。在这里，我们简要概述circRNA的起源和生物合成，并结合circRNA在骨肉瘤肿瘤发生中的最新知识，旨在阐明circRNA在骨肉瘤中的特定作用及其临床意义。

更新日期：2020-05-26

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