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Circulating asymmetric dimethylarginine and cognitive decline: A four‐year follow up study of the 1936 Aberdeen Birth Cohort
International Journal of Geriatric Psychiatry ( IF 3.6 ) Pub Date : 2020-05-25 , DOI: 10.1002/gps.5355
Deborah E Malden 1 , Arduino A Mangoni 2, 3 , Richard J Woodman 4 , Frank Thies 5 , Chris McNeil 6 , Alison D Murray 6 , Roy L Soiza 7
Affiliation  

The underlying mechanisms leading to dementia and Alzheimer's disease (AD) are unclear. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be associated with cognitive decline, but population‐based evidence is lacking.

中文翻译:

循环不对称二甲基精氨酸和认知能力下降:对 1936 年阿伯丁出生队列的四年随访研究

导致痴呆和阿尔茨海默病 (AD) 的潜在机制尚不清楚。不对称二甲基精氨酸 (ADMA) 是一氧化氮合酶的内源性抑制剂,可能与认知能力下降有关,但缺乏基于人群的证据。
更新日期:2020-05-25
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