As contaminant exposures in aquatic ecosystems continue to increase, the need for streamlining research efforts in environmental toxicology using predictive frameworks also grows. One such framework is the adverse outcome pathway (AOP). An AOP framework organizes and utilizes toxicological information to connect measurable molecular endpoints to an adverse outcome of regulatory relevance via a series of events at different levels of biological organization. Molecular endpoints or biomarkers are essential to develop AOPs and are valuable early warning signs of the toxicity of pollutants, including contaminants of emerging concern. Ecological risk‐assessment approaches using tools such as biomarkers and AOPs benefit from identification of molecular targets conserved across species. Bivalve models are useful in such approaches and integral to our understanding of ecological and human health risks associated with contaminant exposures. We discuss the value of using biomarker approaches in bivalve models to meet the demands of twenty‐first‐century toxicology. Environ Toxicol Chem 2020;39:1472–1484. © 2020 SETAC

中文翻译：

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使用双壳类模型的生物标志物工具在开发新兴关注污染物的不良结果途径方面的应用。

随着水生生态系统中污染物暴露的不断增加，使用预测框架简化环境毒理学研究工作的需求也在增长。一种这样的框架是不良结果途径（AOP）。AOP 框架组织和利用毒理学信息，通过生物组织不同级别的一系列事件，将可测量的分子终点与监管相关的不良结果联系起来。分子终点或生物标志物对于开发 AOP 至关重要，并且是污染物毒性的有价值的早期预警信号，包括新出现的污染物。使用生物标志物和 AOP 等工具的生态风险评估方法受益于跨物种保守的分子靶标的识别。双壳类模型在这些方法中很有用，并且对于我们理解与污染物暴露相关的生态和人类健康风险是不可或缺的。我们讨论了在双壳类动物模型中使用生物标志物方法来满足 21 世纪毒理学需求的价值。环境毒物化学2020；39：1472–1484。© 2020 SETAC