Small change, big difference: A series of nonhydrolyzable analogues of bacterial heptosides has been synthesized and assayed on whole cells. Interestingly, depending on the functional groups at the 7‐position of the heptose scaffold and in the vicinity of the anomeric position, some molecules could trigger an inflammatory response whereas others were antagonists of heptose‐1,7‐bisphosphate.

中文翻译：

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不可水解的庚糖双磷酸酯和单磷酸酯类似物调节促炎性TIFA-NF-κB信号传导。

小变化，大差异：合成了一系列细菌七七苷的不可水解类似物，并在全细胞上进行了测定。有趣的是，取决于庚糖支架7位和异头位置附近的官能团，一些分子可能会触发炎症反应，而另一些则是庚糖1,7-双磷酸酯的拮抗剂。