Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells.,ChemBioChem

当前位置： X-MOL 学术 › ChemBioChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-05-26 , DOI: 10.1002/cbic.202000311
Laura Cunningham _{1,

2} , Yong Wang _{3,

4} , Chris Nottingham ₁ , Jammah Pagsulingan ₁ , Gérard Jaouen _{3,

4} , Michael J McGlinchey ₁ , Patrick J Guiry _{1,

2}

Affiliation

Inaccessible no longer: Enantiopure ferrocifens and ferrociphenols have been efficiently prepared for biological evaluation via a chiral ketone by palladium‐catalysed intramolecular direct C−H bond activation/cyclisation. IC₅₀ values reveal that S‐configured molecules perform better against an ER+ breast cancer cell line, but the result is less clear in the ER− case.

中文翻译：

平面手性二茂铁蛋白的对映选择性合成，在乳腺癌细胞的抗增殖活性中表现出手性区分。

不再不可或缺：对映纯的二茂铁和二茂铁酚已通过手性酮通过钯催化的分子内直接C H键活化/环化反应进行了有效的生物学评估。IC ₅₀值显示，S构型的分子对ER +乳腺癌细胞系的性能更好，但在ER-情况下结果不清楚。

更新日期：2020-05-26

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11