Most available 3D biofabrication technologies rely on single-component deposition methods, such as inkjet, extrusion, or light-assisted printing. It is unlikely that any of these technologies used individually would be able to replicate the complexity and functionality of living tissues. Recently, new biofabrication approaches have emerged that integrate multiple manufacturing technologies into a single biofabrication platform. This has led to fabricated structures with improved functionality. In this review, we provide a comprehensive overview of recent advances in the integration of different manufacturing technologies with the aim to fabricate more functional tissue structures. We provide our vision on the future of additive manufacturing (AM) technology, digital design, and the use of artificial intelligence (AI) in the field of biofabrication.

大多数可用的 3D 生物制造技术依赖于单组分沉积方法，例如喷墨、挤出或光辅助打印。单独使用这些技术中的任何一项都不太可能复制活组织的复杂性和功能。最近，出现了将多种制造技术集成到单个生物制造平台中的新生物制造方法。这导致了具有改进功能的制造结构。在这篇综述中，我们全面概述了不同制造技术集成的最新进展，旨在制造更多功能性组织结构。我们提供了对增材制造 (AM) 技术、数字设计以及人工智能 (AI) 在生物制造领域的使用的未来愿景。