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A review of studies exploring fetal alcohol spectrum disorders through eye tracking measures.
Progress in Neuro-Psychopharmacology and Biological Psychiatry ( IF 5.3 ) Pub Date : 2020-05-26 , DOI: 10.1016/j.pnpbp.2020.109980
Pierre Maurage 1 , Zoé Bollen 1 , Nicolas Masson 2 , Fabien D'Hondt 3
Affiliation  

The widespread cognitive and cerebral consequences of prenatal alcohol exposure have been established during the last decades, through the exploration of fetal alcohol spectrum disorders (FASD) using neuropsychological and neuroscience tools. This research field has recently benefited from the emergence of innovative measures, among which eye tracking, allowing a precise measure of the eye movements indexing a large range of cognitive functions. We propose a comprehensive review, based on PRISMA guidelines, of the eye tracking studies performed in populations with FASD. Studies were selected from the PsycINFO, PubMed and Scopus databases, and were evaluated through a standardized methodological quality assessment. Studies were classified according to the eye tracking indexes recorded (saccade characteristics, initial fixation, number of fixations, dwell time, gaze pattern) and the process measured (perception, memory, executive functions). Eye tracking data showed that FASD are mostly associated with impaired ocular perceptive/motor abilities (i.e., altered eye movements, centrally for saccade initiation), lower accuracy as well as increased error rates in saccadic eye movements involving working memory abilities, and reduced inhibitory control on saccades. After identifying the main limitations presented by the reviewed studies, we propose guidelines for future research, underlining the need to increase the standardization of diagnosis and evaluation tools, and to improve the methodological quality of eye tracking measures.



中文翻译:

通过眼动追踪措施探索胎儿酒精谱系障碍的研究综述。

在过去的几十年里,通过使用神经心理学和神经科学工具探索胎儿酒精谱系障碍 (FASD),已经确定了产前酒精暴露的广泛认知和大脑后果。该研究领域最近受益于创新措施的出现,其中包括眼动追踪,可以精确测量索引大量认知功能的眼球运动。我们建议根据 PRISMA 指南对在 FASD 人群中进行的眼动追踪研究进行全面审查。研究选自 PsycINFO、PubMed 和 Scopus 数据库,并通过标准化的方法学质量评估进行评估。根据记录的眼动追踪指标(扫视特征、初始注视、注视次数、停留时间、凝视模式)和测量的过程(感知、记忆、执行功能)。眼动追踪数据显示,FASD 主要与眼部感知/运动能力受损(即眼球运动改变,主要用于扫视启动)、涉及工作记忆能力的扫视眼球运动的准确性降低以及错误率增加以及抑制控制降低有关在扫视上。在确定审查研究提出的主要局限性后,我们提出了未来研究的指导方针,强调需要增加诊断和评估工具的标准化,并提高眼动追踪措施的方法学质量。眼动追踪数据显示,FASD 主要与眼部感知/运动能力受损(即眼球运动改变,主要用于扫视启动)、涉及工作记忆能力的扫视眼球运动的准确性降低以及错误率增加以及抑制控制降低有关在扫视上。在确定审查研究提出的主要局限性后,我们提出了未来研究的指导方针,强调需要增加诊断和评估工具的标准化,并提高眼动追踪措施的方法学质量。眼动追踪数据显示,FASD 主要与眼部感知/运动能力受损(即眼球运动改变,主要用于扫视启动)、涉及工作记忆能力的扫视眼球运动的准确性降低以及错误率增加以及抑制控制降低有关在扫视上。在确定审查研究提出的主要局限性后,我们提出了未来研究的指导方针,强调需要增加诊断和评估工具的标准化,并提高眼动追踪措施的方法学质量。

更新日期:2020-05-26
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