Mitochondrial respiratory chain dysfunction may be predisposing for the development of migraine, reflected in high migraine prevalence in patients with mitochondrial disease. Prevalence and impact of migraine in patients with proven mitochondrial disease and the current treatment efficacy were studied using online questionnaires. Patients were selected at the Internal Medicine Department. Headache was reported by 34 (55%) out of 62 patients. Migraine-criteria were met by 85% of them. Efficacy of migraine treatment was achieved in 4 patients. Given the high prevalence of migraine and current treatment insufficiency, migraine is a major threat of quality of life patients with mitochondrial disease.

中文翻译：

---

线粒体偏头痛; 一项流行、影响和治疗效果队列研究

线粒体呼吸链功能障碍可能是偏头痛发生的诱因，这反映在线粒体疾病患者偏头痛的高患病率上。使用在线问卷研究了偏头痛在已证实的线粒体疾病患者中的患病率和影响以及当前的治疗效果。患者是在内科选择的。62 名患者中有 34 名 (55%) 报告了头痛。其中 85% 的人符合偏头痛标准。4 名患者获得了偏头痛治疗的疗效。鉴于偏头痛的高患病率和目前的治疗不足，偏头痛是线粒体疾病患者生活质量的主要威胁。