Excellent bending behavior is evaluated as the primary factor during the design of biodegradable metal cerebral vascular stents (BMCVSs), which enables vascular stents to be successfully delivered to the targeted location and avoids unnecessary damage to blood vessels. Unfortunately, this bending behavior has been barely investigated which limits the design of BMCVSs with optimal structures. Herein, six BMCVSs were designed and their bending process were simulated using finite element analysis (FEA). Then, the effects of the stent bridge connection type and structure on the bending behavior were systematically analyzed and an universal mathematical model was further established, in which the influence of the structure parameters of the stent bridge on the flexibility of stents was considered. After that, the bending mechanism of the high-stress zone of the bridge was investigated. Finally, the causes and effects of the self-contacting phenomenon as well as the inner-stent protrusion phenomenon in the bending state were analyzed theoretically, and corresponding solutions were proposed to optimize the design of stents. The numerical results show that the stents with the dislocation-line W-shaped unit have better flexibility than the other stents. The flexibility is positively correlated to the cube of the length of linear part and to the square of the curvature of curved part. The self-contacting phenomenon of the bridge during bending can constrain the formation of inner-stent protrusion, which can eliminate the negative effects of the implanted stents on the hemodynamics in blood vessels. This study is expected to provide practical guidance for the structural design of BMCVSs for clinical applications.

在设计可生物降解的金属脑血管支架（BMCVS）期间，评估其出色的弯曲性能是主要因素，这使血管支架能够成功地输送到目标位置，并避免对血管造成不必要的损害。不幸的是，几乎没有研究这种弯曲行为，这限制了具有最佳结构的BMCVS的设计。在此，设计了六个BMCVS，并使用有限元分析（FEA）模拟了它们的弯曲过程。然后，系统地分析了支架桥的连接方式和结构对弯曲行为的影响，并建立了通​​用数学模型，其中考虑了支架桥的结构参数对支架柔韧性的影响。之后，研究了桥梁高应力区的弯曲机理。最后，从理论上分析了在弯曲状态下自接触现象以及支架内突出现象的原因和影响，并提出了相应的解决方案来优化支架的设计。数值结果表明，位错线为W形的​​支架具有比其他支架更好的柔韧性。柔韧性与线性零件长度的立方和弯曲零件曲率的平方呈正相关。桥在弯曲过程中的自接触现象可以限制内部支架突起的形成，从而可以消除植入的支架对血管血液动力学的不利影响。该研究有望为临床应用的BMCVS的结构设计提供实用指导。