Abstract Inspired by the adhesion behavior of scallops, we grafted dopamine hydrochloride onto hyaluronic acid to prepare hydrogels with horseradish peroxidase and H2O2 as triggers. We tested the performance of the hydrogels as tissue adhesives, the results showed that with increasing concentration of horseradish peroxidase and H2O2, the gelation time of these crosslinked hydrogels decreased to about 5 s; at the same time, mechanical strength and wet adhesion strength increased. Because of the outstanding mechanical properties and wet adhesion properties, and biocompatibility on a cellular level, we further investigated the hydrogels for hemostatic testing and skin healing tests. We observed a shortened hemostasis time and significant hemostatic effect in the enzymatically active hyaluronic acid hydrogels relative to the control in rat liver defect and rat artery defect models. In a rat skin injury model, we also observed a promoting effect on skin wound repair by collagen metabolism and the formation of granulation tissue. Therefore, the hydrogel inspired by the adhesion behavior of scallops has the potential to replace sutures in wound healing.

中文翻译：

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受扇贝启发的可快速固化的透明质酸 - 儿茶酚水凝胶作为止血和伤口愈合的组织粘合剂

摘要 受扇贝粘附行为的启发，我们将盐酸多巴胺接枝到透明质酸上，以辣根过氧化物酶和H2O2为触发剂制备了水凝胶。我们测试了水凝胶作为组织粘合剂的性能，结果表明，随着辣根过氧化物酶和 H2O2 浓度的增加，这些交联水凝胶的凝胶时间减少到约 5 秒；同时，机械强度和湿粘合强度增加。由于出色的机械性能和湿粘附性能以及细胞水平的生物相容性，我们进一步研究了用于止血测试和皮肤愈合测试的水凝胶。我们观察到与大鼠肝缺损和大鼠动脉缺损模型中的对照相比，酶活性透明质酸水凝胶的止血时间缩短，止血效果显着。在大鼠皮肤损伤模型中，我们还观察到胶原代谢和肉芽组织形成对皮肤伤口修复的促进作用。因此，受扇贝粘附行为启发的水凝胶有可能取代伤口愈合中的缝合线。