Background

The repair of burns in diabetic patients is a clinical problem. It is relevant to study alternative therapies that can improve the healing process. Our aim was to investigate the effects of Solidago chilensis associated or not with laser on burns in diabetic rats.

Methods

The animals were divided in four groups (n = 30): C- without treatment; S– S. chilensis extract; L-laser irradiated; LS- laser and S. chilensis. In 7, 14 and 21 days samples were collected after the injury to structural, morphometric and molecular analysis.

Results

Our results demonstrate the association of S. chilensis and laser reduced the inflammatory infiltrate and favored the angiogenesis. In the groups treated only with laser or with the plant extract showed higher levels of VEGF. The low-level laser therapy (LLLT) promoted higher collagen I and reduction of collagen III. It was also observed higher MMP-2 activation and a decreasing of the active isoform of MMP-9 in the S, L and LS groups.

Conclusions

The treatments improved the repair of burns in diabetic rats, since it reduced the inflammatory infiltrate and favored the collagen organization presenting similar effects in the burn repair of the diabetics.

中文翻译：

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一枝黄和激光的应用改善了糖尿病大鼠烧伤的修复

背景

糖尿病患者烧伤的修复是一个临床难题。研究可以改善愈合过程的替代疗法是相关的。我们的目的是研究与激光相关或不与激光相关的一枝黄花对糖尿病大鼠烧伤的影响。

方法

将动物分为四组（n = 30）：C-未经治疗；S- S. chilensis提取物；L-激光照射；LS-激光和S. chilensis。在损伤后的第 7、14 和 21 天收集样本进行结构、形态和分子分析。

结果

我们的结果表明S. chilensis和激光的结合减少了炎症浸润并有利于血管生成。在仅用激光或植物提取物处理的组中，显示出更高水平的 VEGF。低水平激光疗法 (LLLT) 促进了更高的胶原蛋白 I 和胶原蛋白 III 的减少。在 S、L 和 LS 组中还观察到更高的 MMP-2 活化和 MMP-9 的活性同种型降低。

结论

这些治疗改善了糖尿病大鼠烧伤的修复，因为它减少了炎症浸润并有利于胶原组织在糖尿病患者的烧伤修复中表现出相似的效果。