The aim of this study was to assess the effects of T-2 toxin–contaminated feed (at concentrations of 1.0 and 1.8 mg/kg) on the rainbow trout immune system by studying non-specific cellular and humoral immune responses and its effect on red and white blood cells. Consumption of T-2 toxin at both concentrations resulted in significantly increased erythrocyte counts and a decrease in mean corpuscular volume. While a significant decrease in mean corpuscular haemoglobin was observed at both experimental concentrations, the decrease in plasma haemoglobin was only significant at the higher T-2 toxin concentration. Higher T-2 toxin concentrations resulted in a significant increase in leukocyte and lymphocyte count, while absolute phagocyte count and counts of less mature neutrophil granulocyte forms remained unchanged at both concentrations. Non-specific humoral immunity (bactericidal activity measured as complement activation) decreased significantly in both experimental groups when compared with the control. The results of this study show that T-2 toxin in feed at a concentration range of 1.0–1.8 mg/kg influences the immunological defence mechanisms of rainbow trout.Trial registration number, MSMT-3876/2014-14; date of registration, 31/1/2014.

中文翻译：

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天花粉真菌毒素T-2毒素对虹鳟（Oncorhynchus mykiss）血液学和免疫学参数的影响。

这项研究的目的是通过研究非特异性细胞和体液免疫应答及其对红色的影响，来评估受T-2毒素污染的饲料（浓度为1.0和1.8 mg / kg）对虹鳟鱼免疫系统的影响。和白细胞。两种浓度下的T-2毒素消耗都导致红细胞计数显着增加，平均红细胞体积减小。虽然在两种实验浓度下均观察到平均红细胞血红蛋白显着降低，但血浆血红蛋白的降低仅在较高的T-2毒素浓度下才显着。较高的T-2毒素浓度导致白细胞和淋巴细胞计数显着增加，而绝对吞噬细胞计数和较不成熟的嗜中性粒细胞形式的计数在两种浓度下均保持不变。与对照组相比，两个实验组的非特异性体液免疫（杀菌活性均以补体激活来衡量）明显降低。这项研究的结果表明，饲料中T-2毒素的浓度范围为1.0–1.8 mg / kg会影响虹鳟鱼的免疫防御机制。注册号MSMT-3876 / 2014-14；注册日期，2014年1月31日。