Background

A bulk of investigations imply that women with rheumatoid arthritis (RA) deliver fewer children in comparison to healthy women.

Purpose

This review article attempts to clarify the involvement of infertility-related issues in both RA men and women. Moreover, the effect of RA disease on the fertility quality and quantity will be discussed.

Results

Declined fertility rate in RA women seems to stem from modified inflammatory settings, advanced maternal age, limited sexual activity, and adverse effects of drugs on ovarian function. Women with RA may have smaller families and seem to be slower to conceive relative to their peer women. The chance of gestation in RA women may drop due to suppressed sexual function through pain and fatigue. In addition, treatment of RA women with non-steroidal anti-inflammatory drugs (NSAIDs) may prevent ovulation and therefore hinder the conception.

Conclusions

A complex interaction between RA disease and fertility related issues is present. Despite an increase rate of infertility in RA females or males, the mechanisms involved in this outcome is still unknown. Plausible causes of the decreased fertility rate in RA patients might be due to inflammatory cytokines, suppressed sexual activity, drug treatments, mother age, personal choice, or a combination of these elements.

中文翻译：

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类风湿关节炎的生育能力和不孕症；最先进的。

背景

大量调查表明，与健康女性相比，类风湿关节炎（RA）产的孩子少。

目的

这篇综述文章试图阐明RA男性和女性中与不育相关的问题。此外，还将讨论RA疾病对生育质量和数量的影响。

结果

RA妇女的生育率下降似乎是由于炎症的改变，产妇年龄的增长，性活动的限制以及药物对卵巢功能的不利影响。患有RA的女性的家庭可能较小，并且相对于同龄女性而言，怀孕的速度似乎较慢。由于疼痛和疲劳导致性功能受到抑制，RA妇女的妊娠机会可能下降。此外，用非甾体类抗炎药（NSAIDs）治疗RA妇女可能会阻止排卵，因此会影响受孕。

结论

RA疾病与生育相关问题之间存在复杂的相互作用。尽管RA女性或男性的不育率增加，但该结果涉及的机制仍未知。RA患者生育率降低的可能原因可能是炎性细胞因子，性活动受到抑制，药物治疗，母亲年龄，个人选择或这些要素的组合。