Abstract

We recently showed that the treatment with Resveratrol (RES) contrasts the effects of ageing on the skeletal muscle (SKM), reduces the appearance of tubular aggregates (TAs), and improves the fatigue resistance. Since fatigue resistance depends on the SKM capillary network, and RES has been described to improve vascularisation, we analysed the SKM capillarization in naturally ageing C57BL/6J male mice, fed with 0.04% RES in the diet for 6 months, which showed a better fatigue resistance in a previous work. Our data show an inverse correlation between the number of capillaries per fibre (CAF) and TAs in both control and treated type IIB fibres, and an increase of CAF in ageing SKM upon RES-treatment. The present work suggests that capillarization is one of the determinants of the development of TAs and fatigue resistance, and that RES can be considered a good candidate to counteract capillary rarefaction in the SKM tissue.

摘要

我们最近显示，白藜芦醇（RES）的治疗可对比衰老对骨骼肌（SKM）的影响，减少管状聚集体（TAs）的出现并提高抗疲劳性。由于抗疲劳性取决于SKM毛细血管网络，并且已经描述了RES可以改善血管生成，因此我们分析了自然衰老的C57BL / 6J雄性小鼠的SKM毛细血管化，在饮食中饲喂0.04％RES的情况持续6个月，这显示出更好的疲劳先前工作中的阻力。我们的数据显示，在对照和处理过的IIB型纤维中，每根纤维的毛细血管数量（CAF）与TA呈负相关，而经RES处理后，老化的SKM中的CAF升高。目前的研究表明，毛细血管化是TAs和抗疲劳性发展的决定因素之一，