Abstract

Adamantane polycyclic polyprenylated acylphloroglucinols (PPAPs) with caged architecture, a special class of hybrid natural products, is specifically rich in the plant family Guttiferae, especially Hypericum or Garcinia genus. Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile. Here we have chosen, screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation. Particularly, the compound, hypersampsone P, blunted the adipocyte differentiation dose-dependently. Moreover, hypersampsone P down-regulated the expressions of several key regulators for adipogenesis, including PPARγ and FABP4. The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.

Graphic Abstract

中文翻译：

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来自无柄金丝桃的 Hypersampsone P 的脂肪生成抑制活性。

摘要

具有笼状结构的金刚烷多环聚异戊二烯酰基间苯三酚 (PPAP) 是一类特殊的混合天然产物，在 Guttiferae 植物中特别丰富，尤其是金丝桃属或藤黄属植物。Hypersampsone P 是从金丝桃中提取的金刚烷 PPAP 化合物之一。在这里，我们选择、筛选了十种PPAP，并鉴定出其中一种显示出抑制脂肪细胞分化的活性。特别是，化合物 hypersampsone P 会剂量依赖性地减弱脂肪细胞的分化。此外，hypersampsone P 下调了几个脂肪生成关键调节因子的表达，包括 PPARγ 和 FABP4。Hypersampsone P 对脂肪形成早期的细胞进行处理可最大程度地减弱脂肪细胞的分化，这种作用可能与 LKB1-AMPK 信号通路有关。

图文摘要