To assess and update the effect of the combination of vitamin D and calcium in the reduction of osteoporotic fractures, a systematic review across Cochrane Database, NIHR HTA database, PubMed and Google Scholar was performed using mesh terms : Cohort studies OR Prospective Studies OR Longitudinal Studies OR Follow-Up Studies OR Incidence OR Risk OR Rate and Osteoporotic Fractures OR Fractures, Bone OR Fractures, Spontaneous OR Spinal Fractures OR Humeral Fractures OR Hip Fractures OR Femoral Neck Fractures AND Vitamin D AND Calcium and key words: vitamin D, fractures, osteoporosis, calcium, dietary supplements. Statistical analysis was performed with Review Manager (RevMan 5.3) using relative risk and confidence interval 95%. The combination reduced total fractures and hip fractures while no effect was observed in wrist fractures. The combination was also well tolerated. Only minor side effects were reported. This systematic review suggests that the combination of vitamin D and calcium can exert a beneficial effect towards osteoporotic fracture reduction.

中文翻译：

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预防骨质疏松性骨折的维生素D和钙的系统评价和荟萃分析。

为了评估和更新维生素D和钙的组合在减少骨质疏松性骨折中的作用，使用网格术语对Cochrane数据库，NIHR HTA数据库，PubMed和Google Scholar进行了系统评价：队列研究或前瞻性研究或纵向研究或随访研究或发病率或风险或发生率和骨质疏松性骨折或骨折，骨或骨折，自发性或脊柱骨折或肱骨骨折或髋部骨折或股骨颈骨折以及维生素D和钙以及关键词：维生素D，骨折，骨质疏松，钙，膳食补充剂。使用Review Manager（RevMan 5.3）使用相对风险和置信区间95％进行统计分析。该组合减少了总骨折和髋部骨折，而在腕部骨折中未观察到效果。该组合也耐受良好。据报道只有轻微的副作用。该系统评价表明，维生素D和钙的组合可对减少骨质疏松性骨折发挥有益作用。