OBJECTIVE Adult-onset Still's disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients. METHODS In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Demographic and clinical data of recruited patients were collected. The Hospital Anxiety and Depression Scale (HADS) and Medical Outcomes Survey Short Form-36 (SF-36) were used to evaluate the mood status and quality of life, respectively. Spearman correlation and multivariable linear regression analyses were used to assess the disease-related risk factors associated with anxiety and depression. RESULTS Forty-four active and thirty-eight relieved patients were enrolled. We found that scores of both HADS anxiety (HADS-A) and depression (HADS-D) subscales in active AOSD were significantly higher than inactive patients, which were significantly higher than controls. Moreover, the HADS-A was positively correlated to the patient's global assessment (PGA), pain, and dosage of prednisone, and the HADS-D was positively correlated to systemic score, PGA, and pain. Female, high dosage of corticosteroids, and PGA more than 50 had a significant association with HADS-A score, while the sore throat and PGA more than 50 had a significant association with HADS-D score. Furthermore, AOSD patients' anxiety and depression had a negative impact on HRQoL. CONCLUSION Active AOSD patients tended to be anxious and depressed, suffering from poorer HRQoL compared to patients in remission. Therefore, the evaluation of mental health and HRQoL should be included in AOSD patients' long-term management.Key Points• Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder leading to multiorgan involvement. This study was so far the first published research focuses on AOSD patients' mental involvement and health-related quality of life (HRQoL).• Active AOSD patients were more tended to be anxious and depressive and suffered from poorer HRQoL compared to inactive patients.• Patients' anxiety and depression were associated with impaired HRQoL.

中文翻译：

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成年Still病患者的焦虑和抑郁以及与健康相关的生活质量的关联。

目的成人成年斯蒂尔病（AOSD）是一种导致多器官受累的自身炎症性疾病。我们试图调查这些患者的情绪状态和与健康相关的生活质量（HRQoL）。方法在本研究中，纳入了82例AOSD患者以及82例年龄和性别匹配的健康对照者。收集招募患者的人口统计学和临床​​数据。医院焦虑和抑郁量表（HADS）和医学成果调查简表-36（SF-36）分别用于评估情绪状态和生活质量。Spearman相关性和多元线性回归分析用于评估与焦虑和抑郁相关的疾病相关危险因素。结果招募了44例活动和38例缓解的患者。我们发现活跃的AOSD中HADS焦虑（HADS-A）和抑郁（HADS-D）分量表的得分均显着高于非活跃患者，后者明显高于对照组。此外，HADS-A与患者的总体评估（PGA），疼痛和泼尼松的剂量呈正相关，而HADS-D与患者的全身评分，PGA和疼痛呈正相关。女性，高剂量的皮质类固醇激素和PGA大于50与HADS-A得分显着相关，而喉咙痛和PGA大于50与HADS-D得分显着相关。此外，AOSD患者的焦虑和抑郁情绪对HRQoL有负面影响。结论活动性AOSD患者倾向于焦虑和沮丧，与缓解期患者相比，HRQoL较差。因此，AOSD患者的长期治疗应包括心理健康和HRQoL的评估。要点•成人发作性斯蒂尔病（AOSD）是一种导致多器官受累的全身性炎症性疾病。迄今为止，这项研究是第一个发表的研究，侧重于AOSD患者的精神参与和与健康相关的生活质量（HRQoL）。•与不活动的患者相比，活动的AOSD患者更容易焦虑和抑郁，遭受的HRQoL较差。患者的焦虑和抑郁与HRQoL受损有关。