The morbidity of SARS-CoV-2 (COVID-19) is reaching 3 Million landmark causing and a serious public health concern globally and it is enigmatic how several antiviral and antibody treatments were not effective in the different period across the globe. With the drastic increasing number of positive cases around the world WHO raised the importance in the assessment of the risk of spread and understanding genetic modifications that could have occurred in the SARS-CoV-2. Using all available deep sequencing data of complete genome from all over the world (NCBI repository), we identified several hundreds of point mutations or SNPs in SARS-CoV-2 all across the genome. This could be the cause for the constant change and differed virulence with an increase in mortality and morbidity. Among the 12 different countries (one sequence from each country) with complete genome sequencing data, we noted the 47 key point mutations or SNPs located along the entire genome that might have impact in the virulence and response to different antivirals against SARS-CoV-2. In this regard, key viral proteins of spike glycoprotein, Nsp1, RdRp and the ORF8 region got heavily mutated within these 3 months via person-to-person passage. We also discuss what could be the possible cause of this rapid mutation in the SARS-CoV-2.

中文翻译：

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SARS-CoV-2的压倒性突变或SNP：注意事项。

SARS-CoV-2（COVID-19）的发病率正在全球范围内引起300万人的里程碑和严重的公共卫生问题，这是谜团，在全球不同时期，几种抗病毒和抗体治疗无效。随着世界各地积极病例的急剧增加，世卫组织在评估传播风险和理解SARS-CoV-2中可能发生的基因改变的重要性方面变得越来越重要。使用来自世界各地（NCBI存储库）的完整基因组的所有可用深度测序数据，我们在整个基因组中识别了SARS-CoV-2中的数百个点突变或SNP。这可能是不断变化和致病力不同，死亡率和发病率增加的原因。在具有完整基因组测序数据的12个不​​同国家（每个国家一个序列）中，我们注意到了整个基因组中的47个关键点突变或SNP，它们可能会影响SARS-CoV-2的毒力和对不同抗病毒药物的反应。在这方面，穗糖蛋白，Nsp1，RdRp和ORF8区的关键病毒蛋白在这三个月内通过人与人的传承而发生了严重的突变。我们还讨论了SARS-CoV-2快速突变的可能原因。在这3个月内，RdRp和ORF8地区通过人对人的传播而发生了严重的突变。我们还讨论了SARS-CoV-2快速突变的可能原因。在这3个月内，RdRp和ORF8地区通过人对人的传播而发生了严重的突变。我们还讨论了SARS-CoV-2快速突变的可能原因。