Patients with Down syndrome are at increased risk of respiratory syncytial virus- and H1N1-related death. Literature on COVID-19 in Down syndrome patients is unavailable thus far. We describe the clinical course of 4 patients with Down syndrome during an outbreak of COVID-19. In all four patients, disease course was severe, warranting hospital care in three patients, with fatal outcome in one patient. Another patient receives supportive care in our institution. Our case series is the first report on probable increased risk of life-threatening disease course of COVID-19 in patients with Down syndrome. Proper surveillance, the adherence of social distancing, and the use of personal protective equipment will be essential in reducing morbidity and mortality in our patients.

唐氏综合症患者发生呼吸道合胞病毒和 H1N1 相关死亡的风险增加。目前尚无关于唐氏综合症患者 COVID-19 的文献。我们描述了 4 名唐氏综合症患者在 COVID-19 爆发期间的临床病程。在所有四名患者中，病程很严重，三名患者需要住院治疗，一名患者死亡。另一名患者在我们机构接受支持治疗。我们的病例系列是关于唐氏综合征患者 COVID-19 危及生命的病程风险可能增加的第一份报告。适当的监测、遵守社交距离和使用个人防护设备对于降低我们患者的发病率和死亡率至关重要。