Membrane proteins are an integral part of signal transduction. To signal, membrane proteins must interact with a variety of lipid species, effectors, and other proteins in the biological membrane leading to an immense number of possible interactions. Despite this inherent complexity, accurate control of signaling must take place. By allowing proteins to adopt a multiplicity of conformations in a process known as allostery, nature is able to transmit a signal from one protein site to another distal, functional site, allowing for modulation of protein properties and regulation of activity. In recent years, an increasing number of reports have pointed to common mechanisms governing the allosteric modulation of membrane proteins, including conformational selection, oligomerization, and the modulation of allosteric sites. In this report, we summarize recent advances in membrane protein allostery.

中文翻译：

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膜蛋白的变构。

膜蛋白是信号转导的组成部分。为了发出信号，膜蛋白必须与生物膜中的各种脂质、效应物和其他蛋白质相互作用，从而导致大量可能的相互作用。尽管存在这种固有的复杂性，但必须对信令进行准确控制。通过允许蛋白质在称为变构的过程中采用多种构象，大自然能够将信号从一个蛋白质位点传输到另一个远端的功能性位点，从而可以调节蛋白质特性和调节活性。近年来，越来越多的报告指出了控制膜蛋白变构调节的常见机制，包括构象选择、寡聚化和变构位点的调节。在这份报告中，