The Hippo pathway plays important roles in organ development, tissue regeneration, and human diseases, such as cancer. In the canonical Hippo pathway, the MST1/2-LATS1/2 kinase cascade phosphorylates and inhibits transcription coactivators Yes-associated protein and transcription coactivator with PDZ-binding motif and thus regulates transcription of genes important for cell proliferation and apoptosis. However, recent studies have depicted a much more complicate picture of the Hippo pathway with many new components and regulatory stimuli involving both chemical and mechanical signals. Furthermore, accumulating evidence indicates that the Hippo pathway also plays important roles in the determination of cell fates, such as self-renewal and differentiation. Here, we review regulations of the Hippo pathway and its functions in stemness and differentiation emphasizing recent discoveries.

中文翻译：

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河马途径在干和分化中的调控和功能。

河马途径在器官发育，组织再生和人类疾病（例如癌症）中起着重要作用。在典型的Hippo途径中，MST1 / 2-LATS1 / 2激酶级联磷酸化并抑制具有PDZ结合基序的转录共激活因子Yes相关蛋白和转录共激活因子，从而调节对细胞增殖和凋亡重要的基因的转录。然而，最近的研究已经描绘了具有许多涉及化学和机械信号的新成分和调控刺激的河马途径的更为复杂的图景。此外，越来越多的证据表明，Hippo途径在确定细胞命运（例如自我更新和分化）中也起着重要作用。这里，