Background:Previous studies have identified low serum uric acid (SUA) levels as a risk factor for the development of Parkinson’s disease (PD). Prodromal PD mainly manifests as a complex of non-motor features, but the association between SUA levels and nonmotor symptoms (NMS) burden level in advanced PD patients is poorly studied. Objective:To determine the association between SUA levels and NMS in PD patients. Methods:Data were gathered from an open label, cross sectional, study with analysis of SUA levels in 87 PD patients and were correlated to NMS through the NMS scale (NMSS). In addition, we examined the possible relation between SUA and NMS burden levels and motor scores. Results:There was a moderate negative association between SUA levels and NMSS total score (ρ= –0.379, p < 0.001). In line with this, we observed that higher NMS burden was associated with lower SUA levels (p < 0.001). Within individual NMSS domains, a moderate negative correlation was observed between SUA levels and the cardiovascular/falls (ρ= –0.285, p = 0.008), sleep/fatigue (ρ= –0.299, p = 0.005), and miscellaneous domains (ρ= –0.318, p = 0.003). Conclusion:In this observational study we observed that SUA levels were negatively associated to NMS burden in PD patients with a specific link to miscellaneous, sleep/fatigue and cardiovascular domains of the NMSS. Interestingly, we did not find a clear relation between SUA and motor scores. Future large-scale prospective studies in de novo and advanced PD are needed to evaluate and establish these associations.

中文翻译：

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帕金森病中的血清尿酸水平和非运动症状。

背景：先前的研究已将低血清尿酸 (SUA) 水平确定为帕金森病 (PD) 发展的危险因素。前驱 PD 主要表现为非运动特征的复合体，但晚期 PD 患者中 SUA 水平与非运动症状 (NMS) 负担水平之间的关联研究甚少。目的：确定PD患者SUA水平与NMS的相关性。方法：数据来自一项开放标签、横断面研究，分析了 87 名 PD 患者的 SUA 水平，并通过 NMS 量表 (NMSS) 与 NMS 相关联。此外，我们检查了 SUA 和 NMS 负担水平与运动评分之间可能的关系。结果：SUA 水平与 NMSS 总分呈中度负相关（ρ= –0.379，p < 0.001）。与此相符，我们观察到较高的 NMS 负担与较低的 SUA 水平相关（p < 0.001）。在单个 NMSS 域中，观察到 SUA 水平与心血管/跌倒 (ρ= –0.285, p = 0.008)、睡眠/疲劳 (ρ= –0.299, p = 0.005) 和其他域 (ρ= –0.318，p = 0.003）。结论：在这项观察性研究中，我们观察到 SUA 水平与 PD 患者的 NMS 负担呈负相关，与 NMSS 的杂项、睡眠/疲劳和心血管领域有特定联系。有趣的是，我们没有发现 SUA 和运动评分之间存在明确的关系。未来需要对新发和晚期 PD 进行大规模前瞻性研究来评估和建立这些关联。在 SUA 水平与心血管/跌倒 (ρ= –0.285, p = 0.008)、睡眠/疲劳 (ρ= –0.299, p = 0.005) 和其他领域 (ρ= –0.318, p = 0.003）。结论：在这项观察性研究中，我们观察到 SUA 水平与 PD 患者的 NMS 负担呈负相关，与 NMSS 的杂项、睡眠/疲劳和心血管领域有特定联系。有趣的是，我们没有发现 SUA 和运动评分之间存在明确的关系。未来需要对新发和晚期 PD 进行大规模前瞻性研究来评估和建立这些关联。在 SUA 水平与心血管/跌倒 (ρ= –0.285, p = 0.008)、睡眠/疲劳 (ρ= –0.299, p = 0.005) 和其他领域 (ρ= –0.318, p = 0.003）。结论：在这项观察性研究中，我们观察到 SUA 水平与 PD 患者的 NMS 负担呈负相关，与 NMSS 的杂项、睡眠/疲劳和心血管领域有特定联系。有趣的是，我们没有发现 SUA 和运动评分之间存在明确的关系。未来需要对新发和晚期 PD 进行大规模前瞻性研究来评估和建立这些关联。在这项观察性研究中，我们观察到 SUA 水平与 PD 患者的 NMS 负担呈负相关，与 NMSS 的杂项、睡眠/疲劳和心血管领域有特定联系。有趣的是，我们没有发现 SUA 和运动评分之间存在明确的关系。未来需要对新发和晚期 PD 进行大规模前瞻性研究来评估和建立这些关联。在这项观察性研究中，我们观察到 SUA 水平与 PD 患者的 NMS 负担呈负相关，与 NMSS 的杂项、睡眠/疲劳和心血管领域有特定联系。有趣的是，我们没有发现 SUA 和运动评分之间存在明确的关系。未来需要对新发和晚期 PD 进行大规模前瞻性研究来评估和建立这些关联。