Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug‐loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post‐fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm⁻². Additional post‐fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.

中文翻译：

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一种通过溶胀效应具有载药能力的自粘式微针贴片。


微针 (MN) 提供了一种通过穿透角质层快速经皮给药的方法。然而，商业转化受到每种药物独特的制造技术的限制。在此，通过水凝胶 MN 贴片的膨胀效应进行载药，探索了一个广泛适用的平台。一系列小分子亲水性、疏水性和生物大分子疗法证明了由甲基丙烯酸透明质酸 (MeHA) 制成的水凝胶 MN 的成功加载和爆发释放。制造后载药过程允许 MeHA MN 贴片的载药量为 10 μg cm ^-2 。使用树枝状聚合物生物粘合剂探索了额外的后制造过程，增加了粘附力，确保在皮肤上的稳定固定，并允许额外的载药策略。