Effect of cobalt manganese ferrite nanoparticles (M-NPs) (Co0.5Mn0.5Fe2O4) on vanadium hazards was assessment in the present study. Four groups of adult male albino rats [control group and three variably treated groups with ammonium metavanadate accompanied with or without cobalt M-NPs] were studied. The oral administration of ammonium metavanadate (Am.V) (20 mg/kg b.wt.) demonstrated the facility of vanadium to distribute and accumulate in the distinctive body organs and ordered as kidney > liver > lung > brain > spleen. Also, Am.V administration induce a significant disturbance in many physiological parameters (RBS, cholesterol, triglyceride, aspartate transaminase, alanine transaminase, Alb., bilirubin, Alk.Ph., urea, creat., Hb%, red blood cell count and packed cell volume) which might be expected to the liberation of free radicals according to the vanadium intoxication or its ability to disturb many body metabolisms. On the other hand, the intraperitoneal administration of 5% M-NPs in parallel with Am.V orally administration showed the ability of M-NPs to reduce Am.V dangerous impacts, which might be resulted from the essentiality of M-NPs metals to the body metabolism and to its free radicals scavenging properties. So, M-NPs could reduce Am.V hazardous effects.

中文翻译：

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钴锰铁氧体纳米颗粒 (Co0.5Mn0.5Fe2O4) 对减少成年大鼠钒酸盐有害作用的影响。


本研究评估了钴锰铁氧体纳米粒子（M-NPs）（Co0.5Mn0.5Fe2O4）对钒危害的影响。研究了四组成年雄性白化大鼠（对照组和三组用偏钒酸铵联合或不联合钴 M-NP 进行不同治疗的组）。口服偏钒酸铵（Am.V）（20 mg/kg b.wt.）证明了钒能够在特定的身体器官中分布和积累，顺序为肾>肝>肺>脑>脾。此外，Am.V 给药还会引起许多生理参数（RBS、胆固醇、甘油三酯、天冬氨酸转氨酶、丙氨酸转氨酶、Alb.、胆红素、Alk.Ph.、尿素、肌酸、Hb%、红细胞计数和根据钒中毒或其扰乱许多身体新陈代谢的能力，预计会释放自由基。另一方面，腹腔注射 5% M-NPs 与 Am.V 口服给药并行，显示出 M-NPs 能够减少 Am.V 危险影响，这可能是由于 M-NPs 金属对身体新陈代谢及其自由基清除特性。因此，M-NP 可以减少 Am.V 的有害影响。