Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method. The fibers were synthesized using a homogenous precipitation method with differing reaction times and were characterized by XRD, FTIR, SEM, and ICP-OES. Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP). No new phases were observed by adding 0.8 wt% of Si during 4 d of precipitation. However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase. The whisker-like fibers were 10–200 µ m in length and 0.2–5 µ m in width. The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by addin...

中文翻译：

---

用含有磷灰石纤维的硅钙石增强的成骨壳聚糖/藻酸盐支架的开发。

采用冷冻干燥法制备了含硅（Si）双相磷酸钙纤维增强的壳聚糖-海藻酸盐（CH-AL）多孔复合支架。纤维使用具有不同反应时间的均相沉淀法合成，并通过 XRD、FTIR、SEM 和 ICP-OES 进行表征。使用 4 天和 8 天的两种不同反应时间在不掺入硅的情况下生产的纤维包含两相羟基磷灰石（~93-96 重量％）和 β-磷酸三钙（β-TCP）。通过在 4 天的沉淀过程中添加 0.8 wt% 的 Si，没有观察到新的相。然而，在回流条件下在 8 d 内向合成的纤维中添加 Si 产生了具有 1.9 wt% Si 的双相纤维，其由与 β-TCP 相相关的新相的硅碳酸盐（~94 wt%）组成。须状纤维的长度为 10-200 µm，宽度为 0.2-5 µm。外加剂制备的复合支架的理化、机械和生物学性能...