OBJECTIVE  Rotator cuff tendon tears are the most common soft tissue injuries in the shoulder joint. Various animal models have been described for this condition, but all current translational animal models have inherent weaknesses in their ability to generate chronically degenerated rotator cuff tendons. The objective of this study was to evaluate a partial infraspinatus tendon transection model as a means of creating a chronically degenerated rotator cuff tendon in an ovine model and compare the injury characteristics of this model to those observed in human patients with severe chronic rotator cuff tendon injuries. STUDY DESIGN  The infraspinatus tendons of six sheep were partially detached followed by capping of the detached medial section of the tendon with Gore-Tex. Human tissue samples of the supraspinatus tendon were harvested from patients undergoing primary reverse shoulder arthroplasty and served as positive controls of chronic rotator cuff tendinopathy. RESULTS  Transected sheep tendons were characterized predominantly by an acute reactive and reparative pathological process as compared with the chronic degenerative changes observed in the human tendons. In contrast, the non-transected portion of the ovine tendon showed histological changes, which were more chronic and degenerative in nature when compared with the transected tendon. CONCLUSION  Overall, histological features of the non-transected portion of ovine tendon were more similar to those observed in the chronic degenerated human tendon.

中文翻译：

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部分Infraspinatus肌腱横断作为一种手段翻译平移的慢性慢性肩袖疾病模型的发展。

目的肩袖腱撕裂是肩关节最常见的软组织损伤。已经针对这种情况描述了各种动物模型，但是所有当前的平移动物模型在生成慢性退化的肩袖肌腱的能力方面都存在固有的弱点。这项研究的目的是评估部分鼻下肌腱横断模型，以在绵羊模型中创建慢性退化的肩袖肌腱，并将该模型的损伤特征与在患有严重慢性肩袖肌腱损伤的人类患者中观察到的损伤特征进行比较。 。研究设计将六只绵羊的鼻下肌腱部分分离，然后用Gore-Tex覆盖腱分离的内侧部分。从进行原发性反向肩关节置换术的患者中收集棘上肌腱的人体组织样本，并将其用作慢性肩袖肌腱病的阳性对照。结果与人类肌腱中观察到的慢性退行性变化相比，横切羊肌腱的主要特征是急性的反应性和修复性病理过程。相反，绵羊肌腱的非横切部分显示出组织学变化，与横切肌腱相比，其本质上更为慢性和退化。结论总体而言，绵羊肌腱非横切部分的组织学特征与慢性变性人肌腱中观察到的组织学特征更为相似。