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Synthesis and biological evaluation of a bioinspired, tissue-adhesive gellan gum-based hydrogel designed for minimally invasive delivery and retention of chondrogenic cells.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-25 , DOI: 10.1039/d0bm00286k David A Learmonth 1 , Pedro M Costa , Tiago R Veloso , Cristiana B Cunha , Mafalda P Cautela , Cristina Correia , Mariana C Vallejo , Rui A Sousa
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-25 , DOI: 10.1039/d0bm00286k David A Learmonth 1 , Pedro M Costa , Tiago R Veloso , Cristiana B Cunha , Mafalda P Cautela , Cristina Correia , Mariana C Vallejo , Rui A Sousa
Affiliation
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A dopamine-modified, bioinspired gellan gum hydrogel (STM-148B) with improved physicochemical and biological characteristics, suitable for minimally invasive cell delivery and retention in the context of cartilage repair, is herein presented. STM-148B's putative game-changing design characteristics include a highly biocompatible, animal-free and chemically defined composition, reproducibility of manufacture and ease of formulation. STM-148B undergoes rapid ionic crossinking by physiologically relevant mono and divalent cations to form stable 3D hydrogels that possess excellent tissue adhesiveness, such that additional fixation aids are rendered superfluous. STM-148B hydrogels maintain viability of mammalian cells and further promote up-regulation of the expression of healthy chondrogenic extracellular matrix markers upon stimulation. STM-148B is currently undergoing pre-clinical safety and efficacy assessment as a medical device for cell delivery and retention focussing on regeneration of hyaline-like cartilage and may represent a valuable addition to the armamentarium of tissue-engineering therapies for treatment of focal cartilage lesions.
中文翻译：
合成和生物学评估的生物启发性，基于组织的结冷胶基水凝胶设计用于微创递送和保留软骨细胞的方法。
本文介绍了具有改善的理化和生物学特性的多巴胺修饰的，生物启发的吉兰糖胶水凝胶（STM-148B），适用于软骨修复背景下的微创细胞递送和保留。STM-148B的公认改变游戏规则的设计特征包括高度生物相容性，无动物和化学成分确定的组成，制造的可重复性和易于配制。STM-148B通过与生理相关的单价和二价阳离子进行快速离子交联，形成稳定的3D水凝胶，该凝胶具有出色的组织粘附性，从而使多余的固定助剂变得多余。STM-148B水凝胶可维持哺乳动物细胞的活力，并在刺激后进一步促进健康的软骨形成细胞外基质标志物的表达上调。
更新日期：2020-06-30
中文翻译：
合成和生物学评估的生物启发性，基于组织的结冷胶基水凝胶设计用于微创递送和保留软骨细胞的方法。
本文介绍了具有改善的理化和生物学特性的多巴胺修饰的，生物启发的吉兰糖胶水凝胶（STM-148B），适用于软骨修复背景下的微创细胞递送和保留。STM-148B的公认改变游戏规则的设计特征包括高度生物相容性，无动物和化学成分确定的组成，制造的可重复性和易于配制。STM-148B通过与生理相关的单价和二价阳离子进行快速离子交联，形成稳定的3D水凝胶，该凝胶具有出色的组织粘附性，从而使多余的固定助剂变得多余。STM-148B水凝胶可维持哺乳动物细胞的活力，并在刺激后进一步促进健康的软骨形成细胞外基质标志物的表达上调。
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