Background: The combination of herbal medicine with conventional treatment increases the survival rate of cancer patients, but the effect is not great. Hyperthermia may have a synergistic effect with herbal medicine alongside conventional medicine. Objective: To monitor the efficacy of hyperthermia together with Gun-Chil-Jung (GCJ) capsule for event-free survival (EFS) and overall survival (OS) for the treatment of various cancers. Methods: We collected data retrospectively on 54 cancer patients of all stages. They were divided into 4 groups according to each hyperthermia or GCJ treatment period. Hyperthermia with 0.46 MHz radiofrequency wave was applied a power of 50 to 100 W for 70 minutes. GCJ capsules were administered orally 3 times a day. Results: The median follow-up was 13.4 months, and 25 (55.6%) patients showed disease-related events. Hyperthermia with GCJ treatment was administered in combination group (n = 36, 66.7%) and traditional Korean medicine-only group (n = 17, 31.5%). The median EFS was 190 days, and the median OS was 390 days. The group of hyperthermia 7 times or fewer and GCJ more than 28 days showed longer EFS and OS. The analysis of superiority between hyperthermia and GCJ showed no significant difference (EFS, P = .55; OS, P = .364). Conclusions: The combination of hyperthermia 1 to 2 times a week with GCJ treatment may improve survival of cancer patients treated or being treated with conventional cancer therapies.

中文翻译：

---

温和热疗和 Gun-Chil-Jung 草药处方联合治疗对 54 名接受化疗或放射治疗的癌症患者的生存益处：一项回顾性研究。


背景：草药与常规治疗相结合可以提高癌症患者的生存率，但效果并不大。热疗可能与草药和传统药物具有协同作用。目的：监测热疗联合 Gun-Chil-Jung (GCJ) 胶囊治疗各种癌症的无事件生存期 (EFS) 和总生存期 (OS) 的疗效。方法：我们回顾性收集了 54 名各个阶段的癌症患者的数据。根据每个热疗或GCJ治疗周期将他们分为4组。使用0.46 MHz射频波进行热疗，功率为50至100 W，持续70分钟。 GCJ胶囊每天口服3次。结果：中位随访时间为 13.4 个月，25 名患者（55.6%）出现疾病相关事件。联合组（n = 36，66.7％）和仅传统韩药组（n = 17，31.5％）进行热疗和GCJ治疗。中位 EFS 为 190 天，中位 OS 为 390 天。热疗7次或更少且GCJ超过28天的组表现出更长的EFS和OS。热疗和 GCJ 之间的优越性分析显示没有显着差异（EFS，P = .55；OS，P = .364）。结论：每周 1 至 2 次热疗与 GCJ 治疗相结合，可以提高接受或正在接受常规癌症治疗的癌症患者的生存率。