This study explored the role of ribophorin II (RPN2) in myelodysplastic syndromes (MDSs) cell proliferation and growth and revealed that RPN2 knockdown suppressed OCI-AML3 cell growth and proliferation and triggered cell cycle arrest and elicited apoptosis in OCI-AML3 cells. In addition, it shed light on the etiology of RPN2's role in MDS cell proliferation that RPN2 can negatively impact enhancer of zeste homolog-2 (EZH2) expression, which in turn is able to modulate the cell cycle location and death in OCI-AML3 cells. Hence, RPN2 expression could be a latent predictor of prognosis in patients with MDS.

中文翻译：

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核糖蛋白II在骨髓增生异常综合症中被上调，并防止细胞凋亡和细胞周期进程。

这项研究探讨了核糖蛋白II（RPN2）在骨髓增生异常综合症（MDSs）细胞增殖和生长中的作用，并揭示了RPN2敲低抑制了OCI-AML3细胞的生长和增殖，并触发了细胞周期停滞并引发了OCI-AML3细胞的凋亡。此外，它揭示了RPN2在MDS细胞增殖中的作用的病因学，即RPN2可能会对zeste homolog-2（EZH2）表达的增强剂产生负面影响，进而能够调节OCI-AML3细胞的细胞周期定位和死亡。 。因此，RPN2表达可能是MDS患者预后的潜在预测指标。