GLP1 receptor agonist liraglutide has been shown to upregulate ACE2 expressions in several animal studies and thereby mediate strong positive stress response. On the other hand, two in silico studies suggest that valproate downregulates ACE2 and AGTR2 gene expressions. In this study, we have evaluated how these two widely used drugs, liraglutide and valproate, change the expression pattern of RAS system genes in the rat lungs. Our results indicate that eight-day treatment with valproate significantly downregulates the gene expression of Agtr2, Mas1 and Agrt1b in the rat lungs. These effects are reversed by co-administration of liraglutide.

中文翻译：

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丙戊酸治疗下调大鼠肺中Agtr2 mRNA

在一些动物研究中，GLP1受体激动剂利拉鲁肽已显示上调ACE2表达，从而介导强烈的正向应激反应。另一方面，两项计算机研究表明丙戊酸酯下调ACE2和AGTR2基因表达。在这项研究中，我们评估了利拉鲁肽和丙戊酸酯这两种广泛使用的药物如何改变大鼠肺中RAS系统基因的表达模式。我们的结果表明，丙戊酸治疗八天可显着下调大鼠肺中Agtr2，Mas1和Agrt1b的基因表达。通过共同施用利拉鲁肽可以逆转这些作用。