Adenosine triphosphate (ATP), as a key substance for regulating tumor progression in the tumor microenvironemnt (TME), is an emerging target for tumor theranostics. Herein, we report a minimalist but versatile nanoplatform with simultaneously TME-responsive drug release, TME-enhanced imaging, ATP-depletion sensitized chemotherapy and photothermal therapy for intelligent tumor theranostics./nMethods: The Fe³⁺ and tannic acid (TA) coordination was self-deposited on doxorubicin (Dox) in a facile method to prepare Dox-encapsulated nanoparticles (DFTNPs)./nResults: When irradiated by a near infrared laser, the DFTNPs could elevate the temperature in the tumor region efficiently. Subsequently, the Dox could be released by the disassembly of Fe³⁺/TA in the TME to initiate chemotherapy. Particularly, the smart nanoagent not only enables ATP-depletion and enhances the therapeutic effect of chemotherapy, but also acts as photothermal transduction agent for photothermal therapy. Moreover, the nanoagent also acts as T₁-weighted MR imaging,photoacoustic imaging and photothermal imaging contrast agent. The mice treated by DFTNPs plus laser showed a complete tumor eradication in 14d observation./nConclusion: This as-prepared versatile nanoplatform offers new insights toward the application of smart nanoagents for improved tumor theranostics.

中文翻译：

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TME激活的具有ATP燃烧能力的治疗药物纳米平台，用于肿瘤敏化和协同治疗。

三磷酸腺苷（ATP）作为调节肿瘤微环境（TME）中肿瘤进展的关键物质，是肿瘤治疗学的新兴靶标。本文中，我们报道了一种极简主义但用途广泛的纳米平台，可同时进行TME响应药物释放，TME增强成像，ATP耗尽致敏化学疗法和光热疗法，用于智能肿瘤治疗学。/n方法： Fe ³⁺和鞣酸（TA）的配位结果表明：当用近红外激光照射时，DFTNPs可以有效地升高肿瘤区域的温度。通过简便的方法，将其自沉积在阿霉素（Dox）上以制备Dox包裹的纳米颗粒（DFTNPs）。随后，可以通过分解Fe ³⁺释放Dox/ TA在TME中开始化疗。特别地，智能纳米剂不仅能够消除ATP并增强化学疗法的治疗效果，而且还可以作为光热疗法的光热传导剂。此外，纳米剂还用作T ₁加权MR成像，光声成像和光热成像造影剂。经DFTNP加激光治疗的小鼠在14d观察中显示出了彻底的肿瘤根除效果。/n结论：如此制备的多功能纳米平台为应用智能纳米剂改善肿瘤治疗学提供了新的见识。