Objectives: Heart, lens, and neuronal cells change significantly with age, and they are older than cells from renewable tissues. Near vision deterioration during aging results from a decrease in accommodation amplitude (AA). Cardiac aging is an independent risk factor for cardiovascular disease. We investigated the association between cardiac aging and AA.Methods: The subjects (500 mean 50-year-old subjects, with equal males and females) were divided into two groups according to AA measured with a Raf ruler. Biomicroscopy was used to capture images of the lens nucleus in the unaccommodated and accommodated state. The nucleus diameter change at 1 D accommodation was measured using ImageJ. Cardiac conduction system differences were evaluated using electrocardiography, and cardiac autonomic aging was assessed based on heart rate variability. Myocardial aging was assessed based on diastolic dysfunction.Results: For near distance vision, compared to subjects who could see clearly from 24 to 28 cm, subjects who could see clearly from 29 to 33 cm had a 2.104-fold higher risk of a lateral e' velocity <10 cm/s [95%CI: 1.312-3.374], 2.603-fold higher risk of diastolic dysfunction [95%CI: 1.453-4.662], 1.54-fold higher risk of a low/high frequency ratio >3.1 [95%CI: 1.085-2.197].Conclusions: As a simple screening test, subjective AA measurement can predict important heart aging parameters, including diastolic dysfunction. ClinicalTrials.gov Registry No: NCT04362215.

中文翻译：

---

当近视困难开始时心脏老化。

目的：心脏、晶状体和神经元细胞随着年龄的增长而发生显着变化，并且它们比可再生组织中的细胞更老。老化过程中近视力恶化是由于调节幅度 (AA) 降低所致。心脏老化是心血管疾病的独立危险因素。我们研究了心脏衰老与AA之间的关系。方法：根据用Raf尺测量的AA将受试者（平均500名50岁的受试者，男女平等）分为两组。生物显微镜用于捕获处于未调节和调节状态的晶状体核的图像。使用 ImageJ 测量 1 D 调节时的核直径变化。使用心电图评估心脏传导系统差异，并根据心率变异性评估心脏自主神经老化。根据舒张功能障碍评估心肌老化。结果：对于近距离视力，与在 24 至 28 厘米范围内可以清楚地看到的受试者相比，在 29 至 33 厘米范围内可以清晰地看到的受试者发生侧向 e 的风险高出 2.104 倍' 速度 <10 cm/s [95%CI: 1.312-3.374]，舒张功能障碍风险高 2.603 倍 [95%CI: 1.453-4.662]，低/高频率比 >3.1 风险高 1.54 倍 [ 95%CI：1.085-2.197]。结论：作为一种简单的筛查测试，主观AA测量可以预测重要的心脏老化参数，包括舒张功能障碍。ClinicalTrials.gov 注册号：NCT04362215。侧向 e' 速度 <10 cm/s [95%CI: 1.312-3.374] 的风险高出 104 倍，舒张功能障碍的风险高出 2.603 倍 [95%CI: 1.453-4.662]，心绞痛的风险高出 1.54 倍低频/高频比>3.1 [95%CI: 1.085-2.197]。结论：作为一种简单的筛查测试，主观AA测量可以预测重要的心脏老化参数，包括舒张功能障碍。ClinicalTrials.gov 注册号：NCT04362215。侧向 e' 速度 <10 cm/s [95%CI: 1.312-3.374] 的风险高出 104 倍，舒张功能障碍的风险高出 2.603 倍 [95%CI: 1.453-4.662]，心绞痛的风险高出 1.54 倍低频/高频比>3.1 [95%CI: 1.085-2.197]。结论：作为一种简单的筛查测试，主观AA测量可以预测重要的心脏老化参数，包括舒张功能障碍。ClinicalTrials.gov 注册号：NCT04362215。