Abstract

Purpose

The present study investigated the role of free curcuminoids bioavailability on the relative radioprotective efficacy of natural unformulated curcuminoids.

Materials and Methods

A food-grade bioavailable formulation of curcuminoids as curcumagalactomannosides (CGM) and unformulated curcuminoids (UC) were employed for the study. Swiss albino mice were randomized into Normal control, Radiation control, Radiation + UC, and Radiation + CGM groups and irradiated with γ-radiation of 6, 8, 10 and 12 Gy. Survival rate, hematological and biochemical parameters, bone marrow cellularity, chromosomal aberrations and histopathology of intestine were followed as a measure of the relative efficacy.

Results and Discussion: Oral administration with both UC and CGM at 100 mg/kg. b.wt. produced significant radioprotective effect over the untreated control group of animals. However, CGM treatment was found to provide better clastogenic and genotoxic potential as compared to UC. Further, the histopathology analysis of intestine confirmed the better protective effect of CGM over UC-treated animals.

Conclusion

The present study demonstrated the positive role of the bioavailability of curcuminoids in the amelioration of radiation-induced damages in mice since CGM treatment exerted better survival rate and radioprotective effect as compared with UC, despite the relatively low concentrations of curcuminoids in CGM (39% w/w).

中文翻译：

---

姜黄素对小鼠辐射诱导损伤的改善：生物利用度的作用

摘要

目的

本研究调查了游离姜黄素生物利用度对天然未配制姜黄素的相对辐射防护功效的作用。

材料和方法

该研究采用了姜黄素的食品级生物可利用配方，如姜黄半乳甘露糖苷 (CGM) 和未配制的姜黄素 (UC)。瑞士白化小鼠被随机分为正常对照组、放射对照组、放射 + UC 和放射 + CGM 组，并接受 6、8、10 和 12 Gy 的 γ 辐射照射。存活率、血液学和生化参数、骨髓细胞构成、染色体畸变和肠的组织病理学被跟踪作为相对功效的量度。

结果和讨论： UC 和 CGM 以 100 mg/kg 口服给药。重量 对未处理的对照组动物产生显着的辐射防护作用。然而，与 UC 相比，发现 CGM 治疗提供了更好的致断裂和基因毒性潜力。此外，肠道的组织病理学分析证实了 CGM 比 UC 治疗的动物更好的保护作用。

结论

本研究表明，尽管 CGM 中姜黄素的浓度相对较低（39% w /w)。