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Clinicopathologic characteristics and survival of patients with primary effusion lymphoma.
Leukemia & Lymphoma ( IF 2.2 ) Pub Date : 2020-05-25 , DOI: 10.1080/10428194.2020.1762881
Cristian Aguilar 1 , Caddie Laberiano 2, 3 , Brady Beltran 4 , Cecilia Diaz 5 , Alvaro Taype-Rondan 6 , Jorge J Castillo 7
Affiliation  

Primary effusion lymphoma (PEL) is an aggressive B-cell lymphoma confined to body cavities and universally associated with human herpesvirus type 8 infection. The prognosis of this entity remains poor, with a median survival time of 6 to 9 months. To better understand the clinicopathologic features of the disease and identify possible prognostic factors, we performed a systematic review of the literature for cases of PEL, including 2 previously unreported cases from our institution. PEL was more prevalent in men (92%), with a median age at diagnosis of 55 years. The median overall survival for the entire series was 6 months. Peritoneal involvement (HR:1.62; 95% CI:1.06–2.48) and elevated serum lactate dehydrogenase (LDH) levels (HR:2.50; 95% CI:1.21–5.19) were associated with higher risk of death, while pericardial involvement (HR:0.43; 95% CI:0.20–0.94) was associated with lower risk of death. Therefore, effusion site and serum LDH levels are potential prognostic factors in patients with PEL.



中文翻译:

原发性积液性淋巴瘤患者的临床病理特征和生存率。

原发性渗出性淋巴瘤(PEL)是一种侵袭性B细胞淋巴瘤,仅局限于体腔且普遍与8型人类疱疹病毒感染相关。该实体的预后仍然很差,中位生存时间为6到9个月。为了更好地了解该疾病的临床病理特征并确定可能的预后因素,我们对PEL病例的文献进行了系统的综述,包括本机构2例以前未报告的病例。PEL在男性中更为普遍(92%),诊断中位年龄为55岁。整个系列的中位总生存期为6个月。腹膜受累(HR:1.62; 95%CI:1.06-2.48)和血清乳酸脱氢酶(LDH)水平升高(HR:2.50; 95%CI:1.21-5.19)与更高的死亡风险相关,而心包受累(HR) :0.43; 95%CI:0。20-0.94)与较低的死亡风险相关。因此,积液部位和血清LDH水平是PEL患者的潜在预后因素。

更新日期:2020-05-25
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