Elevation of nonfasting triglyceride (TG) levels above 1.8 g/L (2 mmol/L) is associated with increased risk of cardiovascular diseases. Exacerbated postprandial hypertriglyceridemia (PP–HTG) and metabolic context both modulate the overall efficacy of the reverse cholesterol transport (RCT) pathway, but the specific contribution of exaggerated PP–HTG on RCT efficacy remains indeterminate. Healthy male volunteers (n = 78) exhibiting no clinical features of metabolic disorders underwent a postprandial exploration following consumption of a typical Western meal providing 1200 kcal. Subjects were stratified according to maximal nonfasting TG levels reached after ingestion of the test meal into subjects with a desirable PP–TG response (G_Low, TG < 1.8 g/L, n = 47) and subjects with an undesirable PP–TG response (G_High, TG > 1.8 g/L, n = 31). The impact of the degree of PP–TG response on major steps of RCT pathway, including cholesterol efflux from human macrophages, cholesteryl ester transfer protein (CETP) activity, and hepatic high-density lipoprotein (HDL)-cholesteryl ester (CE) selective uptake, was evaluated. Cholesterol efflux from human macrophages was not significantly affected by the degree of the PP–TG response. Postprandial increase in CETP-mediated CE transfer from HDL to triglyceride-rich lipoprotein particles, and more specifically to chylomicrons, was enhanced in G_High vs G_Low. The hepatic HDL-CE delivery was reduced in subjects from G_High in comparison with those from G_Low. Undesirable PP–TG response induces an overall reduction in RCT efficacy that contributes to the onset elevation of both fasting and nonfasting TG levels and to the development of cardiometabolic diseases.

中文翻译：

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患有不良餐后甘油三酸酯反应的健康男性降低的胆固醇反向转运效率。

非空腹甘油三酯（TG）升高至1.8 g / L（2 mmol / L）以上与心血管疾病的风险增加相关。餐后高甘油三酯血症（PP-HTG）的恶化和代谢环境均会调节胆固醇逆向转运（RCT）途径的总体功效，但夸大的PP-HTG对RCT功效的具体贡献仍然不确定。健康的男性志愿者（n = 78）未表现出代谢异常的临床特征，在进食了提供1200 kcal的典型西餐后进行了餐后检查。根据将试验食物摄入具有理想PP-TG反应的受试者中达到的最大非禁食TG水平进行分层（G_低，TG <1.8 g / L，n= 47）和PP-TG反应不良的受试者（G_高， TG> 1.8 g / L，n = 31）。PP-TG反应程度对RCT途径的主要步骤的影响，包括人类巨噬细胞的胆固醇外流，胆固醇酯转移蛋白（CETP）活性以及肝高密度脂蛋白（HDL）-胆固醇酯（CE）的选择性摄取，进行了评估。PP-TG反应的程度对人巨噬细胞的胆固醇流出没有显着影响。G_高vs G_低增强了CETP介导的从HDL到富含甘油三酸酯的脂蛋白颗粒，特别是到乳糜微粒的CETP餐后转移。G_高组受试者的肝HDL-CE递送减少 与G _Low的比较。不良的PP-TG反应会导致RCT功效整体降低，这会导致空腹和非空腹TG水平的升高以及心血管疾病的发展。