In an era of multidrug-resistant bacterial infections overshadowed by a lack of innovation in the antimicrobial drug development pipeline, there has been a resurgence in multidisciplinary approaches aimed at tackling this global health problem. One such approach is to use metal complexes as a framework for new antimicrobials. Indeed, in this context, bismuth-, silver- and gold-derived compounds in particular have displayed demonstrable antimicrobial activity. In this work, we discuss the antimicrobial and antifungal activities of terpene-derived chiral palladium complexes against Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli, Candida albicans, and Cryptococcus neoformans. It was established that all studied coordination compounds of palladium were highly active antifungal drugs. In contrast, the subset of palladacycles possessing a palladium–carbon bond were only active against the Gram-positive bacterium Staphylococcus aureus. All compounds were inactive against the Gram-negative bacteria tested.

中文翻译：

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萜烯衍生的钯配合物的抗菌和抗真菌活性。

在抗微生物药物开发渠道缺乏创新而被多药耐药细菌感染时代所掩盖的时代，旨在解决这一全球健康问题的多学科方法已经重新兴起。一种这样的方法是将金属络合物用作新的抗菌剂的框架。实际上，在这种情况下，尤其是铋，银和金衍生的化合物显示出可证明的抗菌活性。在这项工作中，我们讨论了萜烯衍生的手性钯配合物对金黄色葡萄球菌，铜绿假单胞菌，肺炎克雷伯菌，鲍曼不动杆菌，大肠埃希菌，白色念珠菌和新隐球菌。已确定所有研究的钯配位化合物均为高活性抗真菌药。相反，具有钯碳键的palladacycles子集仅对革兰氏阳性细菌金黄色葡萄球菌有活性。所有化合物均对测试的革兰氏阴性细菌无活性。